植物丙酮酸脱氢酶系抑制剂类除草剂的合理设计与研究进展  

Rational design and development of plant pyruvate dehydrogenase complex inhibitors as herbicides

作　　者：贺红武[1] 周圆 彭浩[1] HE Hongwu;ZHOU Yuan;PENG Hao(Institute of Pesticide and Organic Chemistry,College of Chemistry,Key Laboratory of Pesticide&Chemical Biology,Ministry of Education,Central China Normal University,Wuhan 430079,China)

机构地区：[1]华中师范大学农药与化学生物学教育部重点实验室化学学院农药与有机化学研究所

出　　处：《农药学学报》2019年第5期580-594,共15页Chinese Journal of Pesticide Science

基　　金：国家重点研发计划(2016YFD0300709-04);国家自然科学基金项目(21172090,20372023,20072008,29572045);国家科技攻关项目(2006BAE01A04-07,2006BAE01A02-9,2004BA308A24-9,2001BA308A02-15,2004BA308 A22-9,97-563-02-05);国家重点基础研究发展(973)计划项目(2003CB114406);教育部项目(214607,230532);湖北省自然科学基金项目(90J26,94J40)

摘　　要：在人们正在努力探索的除草剂新靶标酶中,丙酮酸脱氢酶系(pyruvate dehydrogenase complex,以下简称为PDHc)是一个具有重要意义值得探索的除草剂作用靶标。丙酮酸脱氢酶系是生物体内重要的氧化还原酶之一,其催化丙酮酸氧化脱羧转化成乙酰辅酶A,是生物体内的关键代谢过程。研究表明,许多有机磷类化合物是重要的植物丙酮酸脱氢酶系抑制剂。本文系统介绍了植物丙酮酸脱氢酶系抑制剂作为除草剂的研究历程和研究动态,并结合作者所在课题组的研究工作,从含磷类似物作为植物PDHc抑制剂先导结构的发现、先导化合物的优化以及氯酰草膦的创制和衍生化研究等方面进行了总结和评述。Pyruvate dehydrogenase complex(PDHc)is an important herbicide target enzyme.PDHc is a key oxidoreductase in organism and it catalyzes the oxidative decarboxylation of pyruvate to acetyl coenzyme A.Many organophosphorus compounds have been proven to be effective inhibitors of plant PDHc.In this review,the research progress and trend of PDHc inhibitors as herbicides were systematically introduced.Including the research work of our group,the discovery of phosphorous analogues as lead structures of PDHc inhibitors,optimization of lead compounds,and creation and derivatization of clacyfos were summarized and reviewed.

关 键 词：丙酮酸脱氢酶系 抑制剂 除草剂 生物合理设计 有机磷化合物 研究进展 

分 类 号：S481.1[农业科学—农药学]