Notch信号通路在肺动脉高压肺血管重构中的研究进展  

Advances in research on Notch signaling pathway in pulmonary vascular remodeling of pulmonary arterial hypertension

作　　者：李明星 顾胜龙 应苗法[1] 金烨成 赵蕊[1] LI Ming-xing;GU Sheng-long;YING Miao-fa;JIN Ye-cheng;ZHAO Rui(Dept of Pharmacy,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,China)

机构地区：[1]浙江大学医学院附属邵逸夫医院药剂科

出　　处：《中国药理学通报》2020年第1期5-8,共4页Chinese Pharmacological Bulletin

基　　金：浙江省自然科学基金资助项目(No LYY19H310010);国家自然科学基金资助项目(No 8170140653)

摘　　要：肺动脉高压是一种以肺动脉压力和肺血管阻力持续升高为特征,引起肺血管重构发生的心血管性疾病。Notch信号通路是一种高度保守的信号路径,主要通过调控细胞的增殖、分化及凋亡等过程,参与心血管、神经、肿瘤等疾病的发生、发展。该文主要对Notch信号通路参与肺血管重构发生的分子机制进行综述,以期为肺动脉高压的治疗提供新的策略。Pulmonary hypertension is a cardiovascular disease characterized by persistent elevation of pulmonary artery pressure and pulmonary vascular resistance,causing pulmonary vascular remodeling.Notch signaling pathway is a highly conserved signaling pathway involved in the occurrence and development of cardiovascular,neurological and tumor diseases mainly by regulating cell proliferation,differentiation and apoptosis.This paper mainly reviews the molecular mechanism of Notch signaling pathway involved in pulmonary vascular remodeling,contributing to provide a new strategy for the treatment of pulmonary arterial hypertension.

关 键 词：肺动脉高压 肺血管重构 NOTCH信号通路 肺动脉平滑肌细胞 肺动脉内皮细胞 进展 

分 类 号：R322[医药卫生—人体解剖和组织胚胎学] R322[医药卫生—基础医学]