炎症因子对肺炎支原体肺炎患儿影响的Meta分析  

Meta-analysis of effects of inflammatory factors on children with pneumonia mycoplasma pneumonia

作　　者：李欣[1] 王关涛 吴振起[2] LI Xin;WANG Guan-tao;WU Zhen-qi(The First Clinical College, Liaoning University of Traditional Chinese Medi CIne,Shenyang 110847,Liaoning,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medi CIne,Shenyang 110032,Liaoning,China)

机构地区：[1]辽宁中医药大学第一临床学院,辽宁沈阳110847 [2]辽宁中医药大学附属医院儿科,辽宁沈阳110032

出　　处：《海南医学院学报》2019年第24期1878-1885,1892,共9页Journal of Hainan Medical University

基　　金：国家自然科学基金面上项目(81373687、81874490);辽宁省“百千万人才工程”人选资助项目(辽人社[2018]47号);沈阳市中青年科技创新人才支持计划项目(RC180246)~~

摘　　要：目的评价炎症因子白细胞介素-6(IL-6)、白细胞介素-6(IL-8)、白细胞介素-6(IL-10)、肿瘤坏死因子-α(TNF-α)对肺炎支原体肺炎(MPP)的影响。方法主题词与自由词结合检索CNKI、VIP、CBM、Wan Fang Date、PubMed、SCI encedirect及Google scholor数据库中关于炎症因子对MPP患儿影响的临床随机或半随机对照试验的文献,检索时限均为建库起到2019年5月。由2名评价员根据纳入及排除标准,独立进行筛选文献、提取资料及文献质量评价后,采用RevMan5.3和stata14.0软件进行meta分析。结果共纳入21篇随机对照文献,涉及MPP患儿2744例,健康儿童1095例,结果表明,IL-6水平(SMD=17.74,95%CI=15.38~20.09,P<0.0001)、IL-8水平(SMD=19.40,95%CI=18.12~20.69,P<0.0001))、IL-10水平(SMD=9.51,95%CI=8.25~10.97,P<0.0001)、TNF-a水平(SMD=31.06,95%CI=24.57~37.54,P<0.0001)均明显高于对照组,差异均具有统计学意义。亚组分析重症肺炎支原体肺炎(SMPP)与MPP相比,IL-6水平(SMD=12.02,95%CI=7.08~16.96,P<0.0001)明显高于对照组,差异均具有统计学意义;MPP患儿急性期与恢复期相比,IL-6水平(SMD=20.53,95%CI=17.51~23.56,P<0.0001)、IL-8水平(SMD=17.27,95%CI=10.14~24.40,P<0.0001)、IL-10水平(SMD=6.04,95%CI=1.72~10.36,P<0.0001)、TNF-a水平(SMD=23.64,95%CI=17.60~29.69,P<0.0001)均明显高于对照组,差异均具有统计学意义。结论MPP导致患儿血清中IL-6、IL-8、IL-10、TNF-a炎症因子水平升高,且与疾病严重成正比。Objective To evaluate the effect of mycoplasma pneumoniae pneumonia(MPP)on inflammatory factors.Methods Subject terms and free words were used to search the literature on the effect of children with MPP on inflammatory factors.Data were retrieved from CNKI,VIP,CBM,Wanfang Database,Pubmed Database,SCI encedirect Database and Google scholor,etc.Time period of retrieval was from database established to May 2019.Two researchers conducted literature screening independently according to the inclusion and exclusion criteria,and then processed quality evaluation.RevMan5.3 and stata 14.0 were adopted to conduct meta analysis on all effective indicators.Results A total of 21 studies were involved,including 2744 children with MPP and 1095 healthy children.Results of meta analysis showed IL-6 level(SMD=17.74,95%CI=15.38-20.09,P<0.0001),IL-8 level(SMD=19.40,95%,CI=18.12-20.69,P<0.0001),IL-10 level(SMD=9.51,95%CI=8.25-10.97,P<0.0001),TNF-a level(SMD=31.06,95%CI=24.57-37.54,P<0.0001)were significantly better than the control group;the difference were statistically significant.Subgroup analysis SMPP compared with MPP,IL-6 level(SMD=12.02,95%CI=7.08-16.96,P<0.0001)was significantly better than the control group;the difference were statistically significant.Compared with the recovery period,the acute phase of children with MPP,IL-6 level(SMD=20.53,95%CI=17.51-23.56,P<0.0001),IL-8 level(SMD=17.27,95%CI=10.14-24.40,P<0.0001),IL-10 level(SMD=6.04,95%CI=1.72-10.36,P<0.0001),TNF-a level(SMD=23.64,95%CI=17.60-29.69,P<0.0001)were significantly better than the control group;the difference was statistically significant.Conclusion MPP caused elevated levels of IL-6,IL-8,IL-10,and TNF-a inflammatory factors in the serum of children,and the levels of inflammatory factors were directly proportional to the severity of the disease.

关 键 词：MPP META分析 炎症因子 SMPP 

分 类 号：R725.6[医药卫生—儿科]