心脉隆注射液治疗脓毒症性心功能障碍的疗效观察  

Effect of Xinmailong Injection on sepsis-induced cardiac dysfunction

作　　者：李兴华[1] 程连房[1] 李桂仙[1] 张尧[2] 刘颖[1] 吕艳超[1] 李建放[2] 任亚卿 LI Xing-hua;CHENG Lian-fang;LI Gui-xian;ZHANG Yao;LIU Ying;LV Yan-chao;LI Jian-fang;REN Ya-qing(Intensive Care Unit,Baoding First Central Hospital,Baoding Hebei 071000;Department of Burn and Plastic Surgery,Baoding First Central Hospital,Baoding Hebei 071000;Intensive Care Unit,Wangdu TCM Hospital of Baoding,Baoding Hebei 072450)

机构地区：[1]保定市第一中心医院重症医学科,河北保定071000 [2]保定市第一中心医院烧伤整形科,河北保定071000 [3]保定市望都县中医医院重症医学科,河北望都072450

出　　处：《世界中西医结合杂志》2019年第12期1716-1719,共4页World Journal of Integrated Traditional and Western Medicine

基　　金：2017年保定市科学技术研究与发展指导计划(第二批)项目(17ZF231)

摘　　要：目的探讨心脉隆注射液对脓毒症性心功能障碍的安全性及有效性。方法选取60例脓毒血症引起的心功能障碍患者,随机分为对照组和观察组,每组30例。对照组给予常规治疗,观察组在对照组的治疗基础之上给予心脉隆注射液,治疗1个疗程。观察两组病例心脏指数(CI)、心输出量(CO)、左室舒张末内径(LVDd)、左室射血分数(LVEF)变化,血清中NT-proBNP、肌钙蛋白(cInI),超敏C反应蛋白(hs-CRP)、降钙素原(PCT)变化,不良反应及死亡率情况。结果经过治疗,观察组总有效率明显高于对照组(P<0.05),差异具有统计学意义。与对照组比较,观察组治疗后心功能CI、CO均明显增加,LVDd值缩小,LVEF值升高,血清中BNP、cInI、PCT及hs-CRP含量均明显降低(P<0.05),差异具有统计学意义。与对照组比较,观察组ICU住院时间明显缩短,死亡率明显降低(P<0.05),差异具有统计学意义。结论心脉隆注射液可有效改善脓毒血症患者心功能,降低BNP水平,减少ICU住院时间,降低不良反应发生率及死亡率,提高患者的生存质量。Objective To investigate the safety and efficacy of Xinmailong Injection in the treatment of sepsis-induced cardiac dysfunction.Methods 60 patients with cardiac dysfunction caused by sepsis were divided into the control group(n=30)and the observation group(n=30).The control group was given routine treatment,and the observation group was given Xinmailong injection on the basis of the control group for 4 courses of treatment.The changes of cardiac function indexes(CI),cardiac output(CO),left ventricular end diastolic diameter(LVDd),left ventricular ejection fraction(LVEF),serum NT-proBNP,troponin(cInI),hypersensitive C-reactive protein(hs-CRP),procalcitonin(PCT),adverse reactions and mortality rate in both groups were observed.Results After treatment,the total effective rate of the patients in the observation group was significantly higher than that in the control group,with statistical significance(P<0.05).Compared with the control group,the observation group had significant increases in CI,CO and LVEF(P<0.05),and significant reductions in LVDd,serum BNP,cInI,PCT and hs-CRP(P<0.05)with significance.Compared with the control group,the observation group had shorter ICU hospitalization time,lower mortality rate than the control group with significance(P<0.05),and without adverse reactions.Conclusion Xinmailong Injection can effectively improve cardiac function,reduce BNP level,reduce ICU hospitalization time,reduce adverse reactions and mortality rate,and improve quality of life of the patients with sepsis-induced cardiac dysfunction.

关 键 词：脓毒血症 心脉隆注射液 心功能障碍 

分 类 号：R459.7[医药卫生—急诊医学]