虹膜曲率定量测量及在可疑原发性房角关闭虹膜曲率评估中的应用  

Quantitative Measurement of Iris Curvature and Its Application inEvaluating the Changes in Iris Curvature in Primary Angle Closure Suspect

作　　者：徐志伟[1] 伍海建[1] 金玲艳[1] Zhiwei Xu;Haijian Wu;Lingyan Jin(Department of Ophthalmology,Taizhou Municipal Hospital,Taizhou 318000,China)

机构地区：[1]浙江省台州市立医院眼科,台州市眼科医院,318000

出　　处：《中华眼视光学与视觉科学杂志》2020年第1期14-19,共6页Chinese Journal Of Optometry Ophthalmology And Visual Science

摘　　要：目的:探讨Rhinoceros软件定量测量虹膜前表面曲率的精确性,并用于评估可疑原发性房角关闭(PACS)患者行激光周边虹膜切除术(LPI)前后虹膜曲率的变化。方法:前瞻性研究。选择2016年10月至2019年1月在台州市立医院计划接受LPI治疗的PACS患者16例(16眼)作为PACS组,Allegro Oculyzer眼前节分析系统获取不同轴位的眼前节图像,采用Rhinoceros 5.0软件定量测量虹膜前表面曲率半径,并对眼前节图像成像的一致性及测量方法的一致性进行评价。比较接受LPI治疗前后虹膜曲率的变化,并与年龄、眼别、瞳孔直径匹配的正常人16例(16眼)(作为对照组)进行比较。分析PACS组虹膜曲率与中央前房深度、前房容积、6 mm处周边前房深度之间的相关性,以及LPI治疗前后虹膜曲率变化与中央前房深度变化、前房容积变化、6 mm处周边前房深度变化之间的相关性。采用配对t检验、独立样本t检验及Pearson相关分析对数据进行统计学分析。结果:同一眼眼前节图像成像的变异系数为3.02%,同一图像测量的变异系数为2.54%。PACS组患者虹膜曲率半径为(7.81±1.63)mm,接受LPI治疗后虹膜曲率半径为(9.20±2.22)mm,差异具有统计学意义(t=-9.45,P<0.001)。对照组虹膜曲率半径为(9.99±4.00)mm,与PACS组治疗前相比,差异具有统计学意义(t=-5.69,P<0.001)。PACS组在校正中央前房深度后,0°(r=0.879,P<0.001)、90°(r=0.684,P=0.005)、180°(r=0.619,P=0.014)、270°(r=0.740,P=0.002)轴位虹膜曲率半径与对应轴位6 mm处周边前房深度之间均有相关性。在接受LPI治疗后,除下方270°(r=0.453,P=0.078)轴位方向外,0°(r=0.693,P=0.003)、90°(r=0.560,P=0.024)、180°(r=0.580,P=0.019)轴位虹膜曲率变化量与对应轴位6 mm处周边前房深度变化量之间均有相关性。结论:该虹膜曲率定量测量方法具有较好的精确性和可重复性,并可用于PACS的早期诊断及治疗疗效的量化评估。Objective:To evaluate the accuracy of the quantitative measurement of iris curvature by Rhinoceros and to assess the changes iniris curvature in primary angle closure suspect after laser periphery iridectomy(LPI).Methods:This was a prospective study.Sixteen patients(16 eyes)with primary angle closure suspect(PACS)who planned to undergo LPI treatment in Taizhou Municipal Hospital were selected.The anterior segment images of different axes were captured by Allegro Oculyzer.The curvature radius of the anterior iris surface was quantitatively measured by Rhinoceros 5.0.The repeatability of image capturing and image measurement was assessed.The iris curvature of the patients with PACS was compared before and after LPI.Sixteen normal persons(16 eyes)matched for age,sex,and pupil size were selected as the control group.The iris curvature was compared between the PACS and control groups.The correlation between iris curvature and central anterior chamber depth,anterior chamber volume and peripheral anterior chamber depth at 6 mm in the PACS group were analyzed.The correlation between changes in iris curvature and central anterior chamber depth,anterior chamber volume,and 6 mm peripheral anterior chamber depth before and after LPI treatment were also analyzed.A paired t test,independent t test and Pearson correlation coefficient were used for statistical analysis.Results:The coefficient of variation of anterior segment image capturing was 3.02%.The coefficient of variation of anterior segment image measurement was 2.54%.The radius of the iris curvature in the PACS group was 7.81±1.63 mm,which increased to 9.20±2.22 mm after LPI(t=-9.45,P<0.001).The radius of the iris curvature in the control group was 9.99±4.00 mm.The difference between the PACS group and control group was statistically significant(t=-5.69,P<0.001).After correction for the central anterior chamber depth,there was a correlation between the iris curvature radius in the direction of 0°(r=0.879,P<0.001),90°(r=0.684,P=0.005),180°(r=0.619,P=0.014),270°(r=

关 键 词：虹膜曲率 定量测量 可疑原发性房角关闭 

分 类 号：TP3[自动化与计算机技术—计算机科学与技术]