疏血通脉胶囊治疗急性脑梗死60例临床疗效评价  

Clinical evaluation of shuxuetongmai capsule in treating acute cerebral infarction

作　　者：杜忠剑 冉思邈 张青萍[2] 刘泰[2] 刘永辉[2] 谭庆晶[2] 王天宝 DU Zhongjian;RAN Simiao;ZHANG Qingping;LIU Tai;LIU Yonghui;TAN Qingjing;WANG Tianbao(Guangxi Traditional Chinese Medical University,Nanning,Guangxi 530001,China;Department of Encephalopathy,First Affiliated Hospital of Guangxi Traditional Chinese Medical University,Nanning,Guangxi 530023,China)

机构地区：[1]广西中医药大学,广西南宁530001 [2]广西中医药大学第一附属医院脑病科,广西南宁530023

出　　处：《安徽医药》2020年第1期13-16,共4页Anhui Medical and Pharmaceutical Journal

基　　金：广西壮族自治区中医药管理局面上课题（GZPT1208)

摘　　要：目的明确疏血通脉胶囊对急性脑梗死的临床疗效。方法将2015年至2018年6月广西中医药大学第一附属医院脑病科180例诊断为急性脑梗死(痰瘀互结证)的病人采用随机数字表的方法分为治疗组、中药对照组和对照组,每组均为60例,治疗组予疏血通脉胶囊治疗,空腹口服,一次2粒(1.0 g);对照组予丁苯酞软胶囊治疗,空腹口服,一次2粒(0.2 g);中药对照组予利脑心胶囊治疗,饭后口服,一次4粒(1.0 g);均是一日三次,4周为一疗程。疗程结束后观察三组病人NIHSS(美国国立卫生研究院卒中量表)评分、ADL(日常生活活动能力)评分、SAS/SDS(焦虑/抑郁自评量表)评分、及病后常见并发症发生情况。结果三组病人治疗前后NIHSS评分、ADL评分变化对比,三组病人治疗前NIHSS评分、ADL评分比较差异无统计学意义(P>0.05),治疗后均较前改善,差异有统计学意义(P<0.05),治疗组及中药对照组病人NIHSS评分、ADL评分改善情况较对照组好[NIHSS评分:(4.32±1.03)比(4.54±1.20)比(7.87±1.32)][ADL评分:(78.32±6.25)比(76.45±5.96)比(57.54±5.43)](P<0.01),治疗组与中药对照组相比,治疗后NIHSS评分、ADL评分比较差异无统计学意义(P>0.05)。三组病人均出现梗死后常见并发症,治疗组和中药对照组梗死后出血、吸入性肺炎、低蛋白血症以及使用抗焦虑药物的人数均少于对照组(P<0.05),治疗组和中药对照组上述4大指标对比则差异无统计学意义(P>0.05)。三组病人中出现焦虑的病人中进行SAS/SDS评分,三组病人在治疗后SAS、SDS评分均下降(P<0.05),其中治疗组与中药对照组病人评分比对照组低(P<0.05),治疗组与中药对照组评分差异无统计学意义(P>0.05)。治疗组和中药对照组在改善NIHSS评分、ADL评分、SAS/SDS评分中作用优于对照组(P<0.05),且两组在梗死后出血、吸入性肺炎、低蛋白血症、使用抗焦虑药物的人数以及抗焦虑效果均少于或优于对照组(P<Objective To clarify the clinical effect of shuxuetongmai Capsule on acute cerebral infarction.Methods 180 patients with acute cerebral infarction(phlegm and blood stasis syndrome)in from January 2015 to June 2018 were randomly divided into the treatment group,the Chinese medicine control group and the control group,with 60 patients in each.The treatment group was treated with shuxuetongmai capsule(0.5 g/capsule),which was taken orally on an empty stomach,2 capsules(1 g)at a time,3 times a day,4 weeks as a course of treatment.The control group was treated with conventional bupropion soft capsule treatment(0.1g/capsule),take orally on an empty stomach,2 capsules(0.2 g)at a time,three times a day,four weeks as a course of treat⁃ment The control group of traditional Chinese medicine was treated with linanxin capsule(0.25 g/capsule),take orally after meals,four capsules(1 g)at a time,three times a day,four weeks as a course of treatment.After the treatment,NIHSS,ADL,SAS/SDS and common complications were observed.Results There was no significant difference in NIHSS score and ADL score before and af⁃ter treatment among the three groups(P>0.05).However,after treatment,they were improved(P<0.05).The improvement of NI⁃HSS score and ADL score in the treatment group and the traditional Chinese medicine control group was better than that in the con⁃trol group[NIHSS:(4.32±1.03)vs.(4.54±1.20)vs.(7.87±1.32)][ADL:(78.32±6.25)vs(.76.45±5.96)vs.(57.54±5.43)](P<0.01)There was no significant difference in NIHSS score and ADL score between the two groups(P>0.05).The common complications of the three groups.Post infarction hemorrhag,aspiration pneumonia and hypoproteinemia were compared.The patients in the treatment group and the traditional Chinese medicine control group were less than those in the control group(P<0.05).There was no signifi⁃cant difference between the treatment group and the traditional Chinese medicine control group(P>0.05).The SAS/SDS scores of patients with anxiety in the three groups were lower th

关 键 词：脑梗死 中草药 肺炎 吸入性 低蛋白血症 焦虑 疏血通脉胶囊 

分 类 号：R47[医药卫生—护理学]