有氧运动联合锝[99Tc]-亚甲基二膦酸盐对老年骨质疏松骨密度及血清抗酒石酸酸性磷酸酶5b的影响  

Effects of aerobic exercise combined with technetium [99Tc]-methylenediphosphonate on the bone density and the serum TRACP5b in elderly patients with osteoporosis

作　　者：杨云凤[1] 刘菊华[1] 吴碧华[1] 辜建伟[1] 刘利[1] 董文菊[1] YANG Yunfeng;LIU Juhua;WU Bihua;GU Jianwei;LIU Li;DONG Wenju(Department of Geriatrics,Affiliated Hospital of North Sichuan Medical College,Nanchong,Sichuan 637000,China)

机构地区：[1]川北医学院附属医院老年病科

出　　处：《安徽医药》2020年第1期128-131,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨有氧运动联合云克(锝[99 Tc]-亚甲基二膦酸盐注射液)对老年骨质疏松病人骨密度及血清TRACP5b的影响。方法选取2017年7月至2018年7月期间川北医学院附属医院老年病科收治的老年骨质疏松症病人90例作为研究对象,将90例病人采用随机数字表法分为两组,对照组45例病人给予常规抗骨质疏松药物及云克治疗,研究组45例病人在对照组的治疗基础上给予有氧运动治疗,观察两组治疗前后骨密度、血清TPⅠNP(总Ⅰ型前胶原氨基端延长肽)、β⁃CTX(Ⅰ型胶原羧基端肽β特殊序列)、TRACP5b(人抗酒石酸酸性磷酸酶5b)及生活质量变化等指标。结果治疗前,两组病人各个部位骨密度对比差异无统计学意义(P>0.05),治疗后[研究组的骨密度分别是腰椎(0.889±0.017)g/cm2、股骨颈(0.775±0.013)g/cm2、股骨大转子(0.697±0.013)g/cm2、股骨三角区(0.654±0.018)g/cm2]有明显改善(P<0.05)。治疗前,两组病人血清P1NP、β⁃CTX、TRACP5b等含量变化差异无统计学意义(P>0.05),治疗后[研究组依次是β⁃CTX为(0.17±0.03)pg/mL、P1NP为(85.46±5.98)μg/mL、TRACP5b为(4.54±0.56)pg/mL]差异无统计学意义(P<0.05)。治疗前,两组病人生活质量对比差异无统计学意义(P>0.05),治疗后都有明显改善(P<0.05),总分为8.32±1.85。结论有氧运动联合云克治疗老年骨质疏松症,可有效提高骨密度,改善血清骨转化指标,提高病人生活质量,具有较高的临床应用价值。Objective To investigate the effect of aerobic exercise combined with Yunke(technetium[99 Tc]⁃methylendiphospho⁃nate injection)on the bone density and the serum TRACP5b in elderly patients with osteoporosis.Method A total of 90 cases of el⁃derly patients with osteoporosis admitted to the Affiliated Hospital of North Sichuan Medical College from July 2017 to July 2018 were selected as the study objects and were randomly divided into the control group(n=45)and the study group(n=45).The pa⁃tients in the control group were treated with conventional drugs and Yunke,while the patients in the study group were treated with aer⁃obic exercise on the basis of the treatment in the control group.Bone density,serum P1NP,beta CTX,TRACP5b tartrate resistant acid phosphatase 5 b and the change of quality of life index were observed before and after treatment in the two groups.Results Before treatment,there was no significant difference in bone mineral density of every location between the two groups(P>0.05).After treat⁃ment,the bone mineral density was significantly improved in the study group(P<0.05).Before treatment,the serum P1NP,β⁃CTX,TRACP5b and quality of life of patients showed no significant difference between the two groups(P>0.05).After treatment,the above was significantly improved in the study group(P<0.05).Conclusion Aerobic exercise combined with Yunke could effectively im⁃prove the bone mineral density,improve the bone transformation index,improve the quality of life and had higher application value.

关 键 词：骨质疏松 骨密度 身体锻炼 太极 有氧运动 锝[99 Tc]-亚甲基二膦酸 抗酒石酸酸性磷酸酶 生活质量 老年人 

分 类 号：R58[医药卫生—内分泌]