肿瘤中Dapper蛋白家族表观遗传调控的研究进展  

Epigenetic regulation of Dapper family proteins in cancer

作　　者：吴娟 吴勇军 李智[2] 曾长 李振丰 唐仪 卢淼 张雪纯[3] 张万勇 王丹慧 刘晨睿 WU Juan;WU Yongjun;LI Zhi;ZENG Chang;LI Zhenfeng;TANG Yi;LU Miao;ZHANG Xuechun;ZHANG Wanyong;WANG Danhui;LIU Chenrui(Department of Pathology,the Affiliated of Xiangtan Hospital of South China University,the First People's Hospital of Xiangtan City,Xiangtan 411100,Hunan,China;Department of Clinical Pharmacology,Xiangya Hospital,Central South University, Changsha 410008,Hunan,China;Department of Pathology,the Second People's Hospital of Yueyang City,Yueyang 414000,Hunan,China;Department of Oncology,the Affiliated of Xiangtan Hospital of South China University,the First People's Hospital of Xiangtan City,Xiangtan 411100,Hunan,China)

机构地区：[1]南华大学附属湘潭医院湘潭市第一人民医院病理科,湖南湘潭411100 [2]中南大学湘雅医院临床药理研究所,湖南长沙410008 [3]南华大学附属岳阳市二人民医院病理科,湖南岳阳414000 [4]南华大学附属湘潭医院湘潭市第一人民医院肿瘤内科,湖南湘潭411100

出　　处：《中国临床药理学与治疗学》2019年第12期1434-1440,共7页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：湖南省自然科学基金科卫联合项目(2018JJ6075)

摘　　要：Dapper是一类Wnt信号通路调控蛋白,与肿瘤发生发展密切相关,通常在正常组织中表达,在肿瘤组织中表达降低或缺失。Dapper蛋白表达降低或表达缺失与基因表观遗传调控相关;Dapper家族基因的表观遗传学改变与肿瘤的病理学特征、疾病进展及预后相关。本综述总结了新近的研究发现,聚焦Dapper家族在肿瘤发生发展中的生物学功能,以及Dapper家族表达的表观遗传学调控的新机制。Dapper family proteins regulate the Wnt signaling pathway and are closely related to cancer initiation and progression.Dapper proteins usually are highly expressed in the normal tissues but often reduced or completely lost in tumors.S uch reduction in expression is mediated by the epigenetic regulation and associated with pathological characteristics,cancer progression and prognosis.Here we review the most recent discoveries in biological functions of Dapper family proteins in cancer initiation and progression as well as the mechanism underlying the epigenetic regulation of the expression of Dapper family proteins.

关 键 词：Dapper 表观遗传学 肿瘤抑制基因 WNT信号通路 

分 类 号：R968[医药卫生—药理学] R73[医药卫生—药学]