维甲酸和Hox基因对哺乳动物畸形耳的影响  

Effects of Retinoic Acid and Hox Genes on Abnormal Ears in Animals

作　　者：周海梅 高山 陈一新 何余湧 ZHOU Haimei;GAO Shan;CHEN Yixin;HE Yuyong(Jiangxi Province Key Laboratory of Animal Nutrition/Engineering Research Center of Feed Development,Jiangxi Agricultural University,Nanchang 330045,China)

机构地区：[1]江西农业大学动物科学技术学院江西省动物营养重点实验室/营养饲料开发工程研究中心

出　　处：《动物营养学报》2019年第12期5485-5492,共8页CHINESE JOURNAL OF ANIMAL NUTRITION

基　　金：国家自然科学基金项目(31560303)

摘　　要：神经嵴细胞在分化发育成耳朵的过程中,任一过程出现异常,都可能会出现耳朵畸形的表型。维甲酸和Hox基因在耳朵的正常发育过程中起着非常关键的作用。维甲酸是维生素A的主要衍生物,是胚胎正常发育所需的微量营养元素之一。Hox基因是一类调控胚胎发育和细胞分化的主要基因。本文就维甲酸和Hox基因与耳朵发育的关系作一综述,旨在进一步阐明畸形耳的形成机制,为进一步明确哺乳动物畸形耳的形成与修复机制作一参考,同时也为减少畸形耳对动物健康和生产性能的不利影响提供参考。During the differentiation and development of neural crest cells into ears,abnormalities in any of the processes may lead to ear malformation phenotypes. Retinoic acid and Hox genes play key roles in the normal development of ear. Retinoic acid is the main derivative of vitamin A and is one of the micronutrients needed for the normal development of embryos. Hox gene is a major gene that regulates embryonic development and cell differentiation. In this paper,ear development and the relation between retinoic acid and Hox genes are reviewed,with an aim of further clarifying the formation and repair mechanism of abnormal ears in mammals,and providing information of howto reduce the bad effects of abnormal ear on animal health and performance.

关 键 词：维生素A 维甲酸 HOX基因 颅神经嵴细胞 畸形耳 

分 类 号：S811.4[农业科学—畜牧学]