羧甲淀粉钠对便秘小鼠的促排便作用  

Effect of sodium carboxymethyl starch on constipation in mice

作　　者：吴曼丽 黄婷婷 杜帅帅 卢伍党 曹永孝 WU Man-li;HUANG Ting-ting;DU Shuai-shuai;LU Wu-dang;CAO Yong-xiao(Department of Pharmacology,Xi'an Jiaotong University Health Science Center,Xi'an 710061,China)

机构地区：[1]西安交通大学医学部药理学系

出　　处：《西安交通大学学报（医学版）》2020年第1期79-83,共5页Journal of Xi’an Jiaotong University（Medical Sciences）

摘　　要：目的探究羧甲淀粉钠的促排便作用。方法小鼠禁食,灌胃洛哌丁胺3 d,制备慢传输型便秘模型;小鼠禁水3 d制备失水燥结型便秘模型,给药后以3 h内排便总粒数、肠推进率、粪便含水率和肠内液体评价羧甲淀粉钠的作用。结果慢传输型便秘模型组造模3 d后排便总粒数为7.9±6.0,羧甲淀粉钠0.45、0.9、1.8 g/kg组排便总粒数分别为18.5±5.0、17.3±8.3和22.9±8.4,与模型组相比明显增多(P<0.01),且效果优于阳性药莫沙必利组(14.3±8.4)。羧甲淀粉钠3个剂量组的肠推进率分别为(75.3±9.2)%、(78.7±9.6)%和(79.4±8.0)%,与模型组(63.0±13.6)%比较均显著增加(P<0.05或P<0.01)。失水燥结型便秘模型组造模3 d后排便总粒数25.8±8.5,羧甲淀粉钠0.9和1.8 g/kg组的排便总粒数分别为37.9±9.9和37.2±7.9,均比模型组显著增加(P<0.01);羧甲淀粉钠1.8 g/kg组肠推进率为(83.2±12.8)%,比模型组(72.6±11.5)%显著增加(P<0.05)。正常对照组大鼠粪便含水率(49.0±6.8)%,羧甲淀粉钠0.3、0.6、1.2 g/kg组分别为(56.0±4.1)%、(57.7±10.4)%和(60.2±6.8)%,与模型组比较均显著增多(P<0.05或P<0.01)。羧甲淀粉钠0.6和1.2 g/kg组大鼠的肠分泌液也比生理盐水组增多(P<0.05或P<0.01)。结论羧甲淀粉钠有改善便秘小鼠排便的作用。Objective To investigate the effect of sodium carboxymethyl starch(CMC)on constipation.Methods The slow transit constipation model of mice was established by intragastric administration of loperamide for 3 d,and the dehydration-dryness constipation model of mice was established by water deprivation for 3 d.The effects of CMC were evaluated by total fecal grains,intestinal propulsion rate,fecal water content and intestinal fluid within 3 h after administration.Results The total defecation granules in the slow transit constipation model group were(7.9±6.0)within 3 h after administration for 3 d.Compared with those in the model group,the total defecation granules in the three CMC dosage groups(0.45,0.9 and 1.8 g/kg)significantly increased(18.5±5.0,17.3±8.3 and 22.9±8.4,P<0.01),respectively.The results were better than those in mosapride group(14.3±8.4).The intestinal propulsion rate[(75.3±9.2)%,(78.7±9.6)%,and(79.4±8.0)%]in the three CMC dosage groups increased significantly(P<0.05 or P<0.01)compared with the model group(63.0±13.6)%.For dehydration and dryness constipation model,the total fecal granules in 0.9 and 1.8 g/kg CMC groups were 37.9±9.9 and 37.2±7.9,which significantly increased compared with those in model group(25.8±8.5,P<0.01).The intestinal propulsive rate(83.2±12.8)%was higher in CMC 1.8 g/kg group than in the model group[(72.6±11.5)%,P<0.05].Mouse fecal water content[(56.0±4.1)%,(57.7±10.4)%and(60.2±6.8%)]in CMC 0.3,0.6 and 1.2 g/kg groups were higher than in the model group[(49.0±6.8)%,P<0.05 or P<0.01].Rat intestinal solution in CMC 0.6 and 1.2 g/kg groups was higher than that in saline group(P<0.05 or P<0.01).Conclusion CMC can improve the defecation of constipated mice.

关 键 词：羧甲淀粉钠 慢传输型便秘 失水燥结型便秘 小鼠 

分 类 号：R965.1[医药卫生—药理学]