光动力肿瘤精准治疗的研究进展  被引量:6

Recent Advances in Photodynamic Therapy for Tumor Precision Treatment

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作  者:赵旭[1,2,3] 赵凯超 刘茄琳 刘雨诗 严秀平 ZHAO Xu;ZHAO Kai-chao;LIU Jia-lin;LIU Yu-shi;YAN Xiu-ping(State Key Laboratory of Food Science and Technology,Jiangnan University,Wuxi 214122;International Joint Laboratory on Food Safety,Jiangnan University,Wuxi 214122;Institute of Analytical Food Safety,School of Food Science and Technology,Jiangnan University,Wuxi 214122;School of Chemical and Material Engineering,Jiangnan University,Wuxi 214122)

机构地区:[1]江南大学食品科学与技术国家重点实验室,江苏无锡214122 [2]江南大学国际食品安全联合实验室,江苏无锡214122 [3]江南大学食品学院,分析食品安全学研究所,江苏无锡214122 [4]江南大学化学与材料工程学院,江苏无锡214122

出  处:《分析科学学报》2019年第6期741-746,共6页Journal of Analytical Science

基  金:国家自然科学基金(No.21804056);江苏省自然科学基金(No.BK20180581);博士后科学基金项目(No.2018M630511);中央高校基础研究经费(No.JUSRP51714B、JUSRP11846)

摘  要:光动力治疗是一种局部、温和及相对安全的治疗模式,在癌症精准治疗方面展现了良好应用前景。光敏剂、光源以及氧气是光动力治疗的三个关键要素。首先,传统小分子光敏剂的吸收光谱大多在紫外或可见光区,且缺乏肿瘤靶向性和特异性,组织穿透深度不足且存在非特异性损伤。其次,光动力治疗效率依赖于外光源连续照射,易引发光毒性和组织损伤。另外,实体肿瘤组织处乏氧等微环境限制了光动力治疗效率。因此,提高光动力治疗效率的同时降低副作用,并实现深层组织的高效特异性治疗,是亟待解决的难题。近年来,新型光动力治疗体系不断涌现,以期解决上述限制光动力治疗进一步发展与应用的瓶颈问题。本文从光动力治疗所需三要素角度,综述了近年来发展的各类新型光动力治疗体系及其在肿瘤精准治疗中的应用进展。Photodynamic therapy(PDT),a localized,moderate and relatively less invasive therapy tool,offers promising opportunities for precision therapy.Photosensitizer,light and oxygen are the three key elements in PDT.However,most of conventional photosensitizers can only be activated by the ultraviolet or visible light and lack of tumor target and specificity,leading to low tissue penetration,insufficient therapeutic efficiency and non-specific damage.Besides,the therapeutic efficiency depends on continuous and long time in-situ irradiation,which inevitably causes severe overheating effect and non-specific damage to normal tissues.Therapeutic efficiency is also limited by the hypoxic microenvironment of solid tumor tissues.Hence,developing novel PDT systems with enhanced anticancer efficiency and reduced side-effect for deep solid tumor therapy is of great importance.In recent years,various novel PDT systems have been developed to solve the above bottleneck problems.In this review,we summarize the recent progress in PDT for tumor precision treatment in view of the three key elements of photosensitizer,light and oxygen.

关 键 词:光动力治疗 精准治疗 光敏剂 光源 氧气补给 

分 类 号:O657.3[理学—分析化学]

 

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