洛阳市接种EV71疫苗后手足口病发病观察  

The observation of hand-foot-mouth disease after Vaccination EV71 Vaccine in Luoyang

作　　者：李克伟[1] 朱鑫[1] 李双玲 LI Kewei;ZHU Xin;LI Shuangling(Luoyang center fo r Disease Prevention and Control,Luoyang^Henan 471023,China)

机构地区：[1]洛阳市疾病预防控制中心

出　　处：《河南预防医学杂志》2020年第1期4-7,15,共5页Henan Journal of Preventive Medicine

摘　　要：目的了解EV71疫苗上市后洛阳市手足口病流行特征,评估EV71疫苗接种效果。方法对临床报告的手足口病人询问并核实疫苗接种信息,对接种疫苗者仍发病者进行流行病学调查。结果 2018年洛阳市共报告手足口病5 926例,接种疫苗后发病510例,占所有病例的8.61%。接种疫苗后发病者的地区、年龄、性别、重症等于总体无统计学差异。疫苗接种后发病的实验室诊断病例64例,其中EV71感染5例,占7.81%;疫苗来源于3个厂家,5例接种后仍感染EV71手足口病患儿临床表现轻微,无重症病例。结论接种EV71疫苗后手足口病流行特征无明显改变,需进一步推广应用,开展效果评价。Objective To analyze the epidemic characteristics of hand-foot-mouth disease in Luoyang after EV71 vaccine came into the market, and to evaluate the effect of EV71 vaccine. Methods To enquire and verify vaccination information for clinically reported patients of hand-foot-mouth disease, and to carry on epidemiological investigation of those still suffering from vaccination. Results A total of 5 926 cases of hand-foot-mouth disease were reported in Luoyang in 2018, 510 Cases were remained after vaccination, That’s 8.61 % of all cases. There were no statistically significant differences in region, age, sex and severity of the patients after vaccination. Among the 64 laboratory-diagnosed cases after vaccination, EV71 infection accounted for 7.81 %.The vaccine originated from three manufacturers,and EV71 hand-foot-mouth disease after inoculation was found to have a Mild clinical presentation, with no serious cases. Conclusions There was no significant change in the epidemic characteristics of hand-foot-mouth disease after EV71 vaccine. Further promote application and effect evaluation is needed.

关 键 词：手足口病 EV71疫苗 评价 

分 类 号：R512.5[医药卫生—内科学]