抑制蛋白在寄生虫感染与免疫中的研究进展  

Research progress in the role of profilin in parasitic infection and immunity

作　　者：秦飞宇 宋海桐 张昕 李雨迪 原飞 何成 刘转转 QIN Fei-yu;SONG Hai-tong;ZHANG Xin;LI Yu-di;YUAN Fei;HE Cheng;LIU Zhuan-zhuan(Jiangsu Key Laboratory of Immunity and Metabolism,Department of Pathogen Biology and Immunology,National Experimental Demonstration Center for Basic Medicine Education,Xuzhou Medical University,Xuzhou 221004,China)

机构地区：[1]徐州医科大学江苏省免疫与代谢重点实验室病原生物学与免疫学教研室基础医学国家级实验教学示范中心

出　　处：《中国寄生虫学与寄生虫病杂志》2019年第6期709-712,共4页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：江苏省自然科学基金青年基金项目(No.BK20180994);江苏省高校自然科学研究基金面上项目(No.17KJB310017);中国博士后第63批面上资助(No.2018M632382);大学生创新创业训练计划项目(No.201910313062Y)~~

摘　　要：抑制蛋白(profilin)是参与调节肌动蛋白动力学的小分子蛋白质,存在于所有真核生物中,结构高度保守。profilin作为一种肌动蛋白结合蛋白,可通过调节肌动蛋白的聚合和解聚,影响寄生虫的运动、入侵及宿主的免疫应答等。本文就profilin的结构与功能、在寄生虫感染与免疫中发挥的作用,以及作为疫苗靶点和佐剂的前景等方面进行综述,以期为寄生虫病的预防和治疗提供新的思路。Profilin is an actin-binding protein highly conserved in all eukaryotes. It regulates the polymerization and depolymerization of actin, therefore affecting parasite movement and invasion in the host and inducing specific immune responses during parasite infection. Here we reviewed the structure and function of profilin, its role during parasite infection and immune responses in the host and its potential as a vaccine candidate and adjuvant, in order to provide reference for the better prevention and treatment of parasitic diseases.

关 键 词：抑制蛋白 寄生虫 感染与免疫 疫苗 

分 类 号：R53[医药卫生—内科学]