日本血吸虫虫卵肉芽肿免疫病理机制研究进展  

Research progress on the immunopathological mechanism of Schistosoma japonicum egg-induced granuloma

作　　者：孙钰浚 李钊琪 吕芳丽 SUN Yu-jun;LI Zhao-qi;LV Fang-li(Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080,China;Department of Parasitology,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou 510080,China;Key Laboratory of Tropical Disease Control of Ministry of Education,Sun Yat-sen University,Guangzhou 510080,China;Provincial Engineering Technology Research Center for Biological Vector Control,Guangzhou 510080,China)

机构地区：[1]中山大学中山医学院2015级临床医学(八年制),广州510080 [2]中山大学中山医学院寄生虫学教研室,广州510080 [3]热带病防治研究教育部重点实验室(中山大学),广州510080 [4]广东省媒介生物防控工程技术研究中心,广州510080

出　　处：《中国寄生虫学与寄生虫病杂志》2019年第6期713-717,722,共6页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：国家自然科学基金(No.81971955);中山大学中山医学院2018年本科教学改革与质量工程建设项目;中山大学研究生院2019年重点发展项目(No.cxjh201908)~~

摘　　要：宿主感染日本血吸虫后,虫卵可沉积于宿主的肝脏和肠壁等组织,引起Th2型为主的免疫应答,导致虫卵肉芽肿的形成和纤维化。该过程涉及多种类型的细胞参与,如中性粒细胞、巨噬细胞、嗜酸粒细胞、自然杀伤细胞、B细胞(包括调节性B细胞)、T细胞[包括辅助性T细胞(Th)1、2和17等细胞亚型]、调节性T细胞、肝星状细胞和肝细胞等。本文综述了参与日本血吸虫虫卵肉芽肿免疫反应的细胞类型及其可能的作用机制,以期为相关工作者提供参考。After infection with Schistosoma japonicum,mature female adult worms lay eggs which deposit in the liver,intestinal wall,and other tissues of the infected mammalian host,which induces predominant Th2 immune responses and causes egg granuloma and fibrosis.It has been reported that neutrophils,macrophages,eosinophils,natural killer cells,B cells(including regulatory B cells),T cells(including Th1,Th2,and Th17 cells),Treg cells,hepatic stellate cells,and hepatocytes are involved in this process.In this paper,we reviewed the cell types involved in the egg granulomatous response of S.japonicum and their possible mechanisms in order to provide a helpful reference for related researchers in this field.

关 键 词：日本血吸虫 虫卵肉芽肿 免疫反应 病理机制 

分 类 号：R383.24[医药卫生—医学寄生虫学]