AIDS合并结核性脑膜炎患者的死亡风险因素分析  

Mortality risk factors in AIDS patients complicated with tuberculous meningitis

作　　者：张哲 汪宇 张玲[1] 逄晓莉 郜桂菊[1] 杨涤[1] 吴亮[1] 赵红心[1] 肖江[1] ZHANG Zhe;WANG Yu;ZHANG Ling;PANG Xiao-li;GAO Gui-ju;YANG Di;WU Liang;ZHAO Hong-xin;XIAO Jiang(First Department of Infectious Diseases,Beijing Ditan Hospital,Capital Medical University,100015,China)

机构地区：[1]首都医科大学附属北京地坛医院感染一科,100015

出　　处：《传染病信息》2019年第6期512-515,共4页Infectious Disease Information

基　　金：“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项(2018ZX10101001-005-001);国家科技重大专项——重大新药创制(2017ZX09304027-001-010);“十三五”国家科技重大专项(2018ZX10715-005);国家自然科学基金(81672000);北京市科学技术委员会:HIV/HBV共感染研究(D161100000416004)。

摘　　要：目的 探讨AIDS合并结核性脑膜炎患者死亡的风险因素,以帮助临床医生尽快制定预防及干预策略,从而降低死亡率。方法 回顾性分析2009年1月—2017年12月北京地坛医院125例AIDS合并结核性脑膜炎入院治疗患者的临床资料。结果 125例患者中有50例(40.00%)于12个月随访期内死亡。低蛋白血症、中枢神经系统病变诊断不明、非AIDS指征性疾病是AIDS合并结核性脑膜炎患者随访期生存率明显下降、死亡风险增加的影响因素。结论 低蛋白血症、中枢神经系统病变诊断不明、非AIDS指征性疾病是导致AIDS合并结核性脑膜炎患者死亡的风险因素。因此,具备这些风险因素的患者,在入院早期应当给予重视及积极的重症监护治疗。Objective To determine the mortality risk factors in AIDS patients complicated with tuberculous meningitis,assist clinical physicians on prioritizing prevention and intervention strategies,and reduce the mortality.Methods Data from 125 AIDS patients complicated with tuberculous meningitis who were hospitalized in Beijing Ditan Hospital from January 2009 to December 2017 were analyzed retrospectively.Results Among 125 patients,50 cases(40.00%)died within 12-month follow-up period.Hypoalbuminemia,unexplained lesions in central nervous system and non-AIDS defining illness were risk factors for the obviously decreased survival rate and increased mortality in AIDS patients complicated with tuberculous meningitis.Conclusions The risk factors of mortality in AIDS patients complicated with tuberculous meningitis include hypoalbuminemia,unexplained lesions in central nervous system and non-AIDS defining illness.Therefore,the patients with these risk factors should be given attention and active intensive care in the early stages of admission.

关 键 词：AIDS 结核性脑膜炎 死亡 风险因素 

分 类 号：R512.91[医药卫生—内科学] R529.3[医药卫生—临床医学]