肾综合征出血热患者血浆MCP-1水平及其临床意义  被引量:3

Plasma levels of MCP-1 in patients with hemorrhagic fever with renal syndrome and its clinical significance

在线阅读下载全文

作  者:王军宁 李晓利[1] 杜虹 白雪帆 王平忠 WANG Jun-ning;LI Xiao-li;DU Hong;BAI Xue-fan;WANG Ping-zhong(Department of Respiratory and Gastroenterology,Honghui Hospital,Xi’an Jiaotong University,710054,China;Department of Infectious Diseases,Tangdu Hospital,Air Force Medical University of PLA,Xi’an 710038,China)

机构地区:[1]西安交通大学附属红会医院呼吸消化内科,710054 [2]空军军医大学唐都医院全军感染病诊疗中心,西安710038

出  处:《传染病信息》2019年第6期521-524,529,共5页Infectious Disease Information

基  金:国家自然科学基金(81373118)。

摘  要:目的 分析肾综合征出血热(hemorrhagic fever with renal syndrome, HFRS)患者不同病期及不同临床型血浆单核细胞趋化蛋白-1(monocyte chemotactic protein-1, MCP-1)浓度变化与疾病相关性,为HFRS临床诊治提供参考依据。方法 以2012年10月—2014年1月期间在空军军医大学唐都医院住院就诊的81例HFRS患者及15例健康志愿者(正常对照组)作为研究对象,用酶联免疫吸附法分别检测其血浆中MCP-1水平,同步检测血常规、肾功能等指标,并分析MCP-1与临床常规检测指标的相关性。结果 在急性期,所有患者血浆MCP-1水平均明显升高,其中重型/危重型患者血浆MCP-1水平升高比轻型/中型更为显著;中型、重型、危重型患者血浆MCP-1水平急性期均高于恢复期及正常对照组(P均<0.05),恢复期与正常对照组比较差异无统计学意义(P>0.05)。Spearman相关分析显示血浆MCP-1水平与白细胞、尿素氮、肌酐水平呈正相关,与血小板水平呈负相关。结论 HFRS患者血浆MCP-1水平与疾病严重程度及疾病进程密切相关。Objective To analyze the correlation between plasma levels of monocyte chemotactic protein-1(MCP-1)and the disease in patients at different phases and of different clinical types of hemorrhagic fever with renal syndrome(HFRS),and provide reference for clinical diagnosis and treatment of HFRS.Methods Eighty-one HFRS patients hospitalized in Tangdu Hospital from October 2012 to January 2014 and 15 healthy volunteers(normal control group)were enrolled as subjects.The plasma MCP-1 levels were measured using enzyme-linked immunosorbent assay.Simultaneous detection of blood routine,renal function and other indicators were performed.The correlation between MCP-1 and clinical routine detection indicators was analyzed.Results At the acute phase,plasma MCP-1 levels were significantly elevated in all patients,and the elevation in the severe/critical patients was more significant than that in the mild/moderate patients.The plasma levels of MCP-1 in the moderate,severe and critical patients at the acute stage were higher than those at the convalescent stage and in normal control group(P<0.05).There was no significant difference in the MCP-1 levels between patients at the convalescent stage and normal controls(P>0.05).Spearman correlation analysis indicated that plasma MCP-1 levels were positively correlated with white blood cells,blood urea nitrogen levels and serum creatinine,while they were negatively correlated with blood platelet levels.Conclusions Plasma levels of MCP-1 are closely correlated with the disease severity and the disease progression in HFRS patients.

关 键 词:汉坦病毒 肾综合征出血热 血浆 单核细胞趋化蛋白-1 

分 类 号:R512.8[医药卫生—内科学]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象