乙型肝炎肝硬化并发肝癌的危险因素探讨  

Risk factors of hepatitis B cirrhosis complicated with liver cancer

作　　者：张睿[1] 朱礼尧[1] 赵艳 ZHANG Rui;ZHU Li-yao;ZHAO Yan(Department of Liver Disease,Huai’an Fourth People’s Hospital,223002,China)

机构地区：[1]淮安市第四人民医院肝病科,223002

出　　处：《传染病信息》2019年第6期539-541,共3页Infectious Disease Information

基　　金：淮安市第四人民医院科研基金(2017003)。

摘　　要：目的 探讨乙型肝炎(乙肝)肝硬化并发肝癌的危险因素,为临床诊治提供依据。方法 回顾性分析我院2016年1月—2018年12月收治的238例乙肝肝硬化患者资料,按照是否并发肝癌分为肝癌组(120例)与非肝癌组(118例),分析乙肝肝硬化并发肝癌的危险因素。结果 肝癌组在性别为男性、肝癌家族史、其他肿瘤家族史、糖尿病史、长期吸烟史、长期饮酒史、HBV阳性及抗病毒治疗的比例方面均高于非肝癌组(P均<0.05)。Logistic回归分析显示,有糖尿病史、有长期饮酒史、有长期吸烟史、HBV阳性及未接受抗病毒治疗是乙肝肝硬化患者并发肝癌的危险因素。结论 男性患者发生乙肝肝硬化的几率高于女性患者。糖尿病史、未接受抗病毒治疗、长期吸烟史、长期饮酒史、HBV阳性均是乙肝肝硬化并发肝癌的危险因素。Objective To investigate the risk factors of hepatitis B cirrhosis complicated with liver cancer and provide evidence for clinical diagnosis and treatment.Methods Data of 238 patients with hepatitis B cirrhosis admitted to our hospital from January 2016 to December 2018 were analyzed retrospectively.The included patients were divided into 2 groups according to the presence/absence of hepatocellular carcinoma,namely liver cancer group(120 cases)and non-liver cancer group(118 cases).The risk factors of hepatitis B cirrhosis complicated with hepatocellular carcinoma were analyzed.Results The percentages of male,family history of liver cancer,family history of other tumors,diabetes history,long-term smoking history,long-term drinking history,positive HBV and antiviral treatment in the liver cancer group were higher than those in the control group(P<0.05).Logistic regression analysis showed that the history of diabetes,long-term drinking history,long-term smoking history,positive HBV and no antiviral treatment were risk factors for liver cancer in patients with hepatitis B cirrhosis.Conclusions Male patients are more prone to hepatitis B cirrhosis than female patients.The risk factors for liver cancer in patients with hepatitis B cirrhosis include the history of diabetes,absence of antiviral treatment,long-term smoking history,long-term drinking history and positive HBV.

关 键 词：乙肝肝硬化 肝癌 危险因素 临床诊治 

分 类 号：R512.6[医药卫生—内科学]