复方丹参滴丸对阿司匹林抵抗冠心病患者的临床作用  

Clinical intervention study of Aspirin Resistance in patients with Coronary Heart Disease by Sonoclot

作　　者：白如冰[1] 宋晓丽 BAI Ru-bing;SONG Xiao-li(Heart Center,Datong Third People’s Hospital,Datong Shanxi 037008,China;Datong Second People’s Hospital,Datong Shanxi 037000,China)

机构地区：[1]山西省大同市第三人民医院心脏中心,山西大同037008 [2]山西省大同市第二人民医院,山西大同037000

出　　处：《药品评价》2019年第18期3-4,9,共3页Drug Evaluation

基　　金：大同市科技局资助——大同市重点发展计划项目(2017092)

摘　　要：目的:观察复方丹参滴丸对阿司匹林抵抗的冠心病患者的临床作用。方法:选240例应用Sonoclot测定血小板功能低下的服用阿司匹林的冠心病患者,随机分为四组,A组(n=60)复方丹参滴联合阿司匹林;B组(n=60)阿司匹林;C组(n=60)阿司匹林加大剂量;D组(n=60)复方丹参滴丸组。1月后用Sonoclot测定CR、PF,观察服药期间心绞痛发作,急性心肌梗死,心源性猝死,出血临床终点事件的发生率。结果:治疗后A组、C组CR、PF水平均显著低于治疗前,B组、D组与治疗前比较无显著性差异。治疗后A组、C组CR、PF水平显著低于B组、D组,有显著性差异。D组心绞痛及心肌梗死事件明显高于其他四组;C组出血事件显著高于其他三组。结论:复方丹参滴丸联合阿司匹林可作为阿司匹林抵抗的一种经济、有效、依存性更好地抑制血小板活性替代方案,可进一步降低急性冠脉事件的发生。Objective: To study the clinical intervention of aspirin resistant patients with coronary heart disease by sonoclot coagulation and platelet function analyzer. Methods: 240 patients with coronary heart disease(CHD)who took Aspirin were selected to measure thrombocytopenia by sonoclot. They were randomly divided into four groups: group A(n=60)with compound Danshen pills and Aspirin, group B(n=60)Aspirin, group C(n=60)Highdose aspirin, group D(n=60)Danshen pills. Determination of CR and PF by sonoclot after one month. The incidence of angina pectoris, acute myocardial infarction, sudden cardiac death and hemorrhage were observed. Results: The level of CR and PF in group of A\C was significantly lower than that before the test, There was no significant difference between group B and group D compared with that before the trial. The level of CR and PF in group A and group C was significantly lower than that in group B and group D after treatment. The incidence of angina pectoris and myocardial infarction in group D was significantly higher than that in the other four groups. The bleeding events in group C were significantly higher than those in the other four groups. Conclusion: Danshen pills combined with aspirin can be used as an economic, effective, and more dependent alternative to inhibit platelet activity, which can further reduce the incidence of acute coronary events.

关 键 词：阿司匹林 抵抗 SONOCLOT 复方丹参滴丸 

分 类 号：R259[医药卫生—中西医结合]