亚低温联合丁苯酞治疗重度急性一氧化碳中毒脑损害的疗效分析  

Curative effect of mild hypothermia combined with butylphthalide on severe acute carbon monoxide poisoning brain damage

作　　者：李兰兰 Li Lanlan(Department of Emergency,Hebei Province Xingtai Third Hospital,Xingtai 054000)

机构地区：[1]河北省邢台市第三医院急诊科

出　　处：《卒中与神经疾病》2019年第6期715-717,共3页Stroke and Nervous Diseases

基　　金：河北省邢台市科技支撑计划项目(2018ZC112)

摘　　要：目的探讨亚低温联合丁苯酞治疗重度急性一氧化碳中毒脑损害的临床疗效。方法将符合标准的患者122例随机分为研究组和对照组各61例,研究组在高压氧等常规治疗基础上加用亚低温及丁苯酞,对照组给予高压氧等常规治疗,观察并比较2组GCS评分、昏迷时间、病死率及迟发性脑病发生率、治疗效果。结果研究组治疗1、2、3 d后GCS评分均高于对照组(P<0.05);研究组昏迷时间(16.74±6.57 h)低于对照组(22.19±7.03 h)(P<0.05);研究组病死率为1.64%,低于对照组6.56%(P>0.05);研究组迟发脑病发生率为18.03%,低于对照组40.98%(P<0.05);研究组痊愈率45.90%、总有效率85.24%,均优于对照组痊愈率26.23%、总有效率65.57%(P<0.05)。结论亚低温联合丁苯酞治疗重度急性一氧化碳中毒脑损害能提高GCS评分,缩短患者的昏迷时间,降低迟发脑病的发生率,可以提高患者的治疗效果和生存质量。Objective To evaluate the clinical efficacy of mild hypothermia combined with butylphthalide in the treatment of severe acute carbon monoxide poisoning.Methods 122 patients who met the criteria were randomly divided into the study group and the control group, 61 cases in each group. The study group was treated with mild hypothermia and butylphthalide on the basis of conventional therapy such as hyperbaric oxygen, while the control group was treated with conventional therapy. The GCS score, coma time, mortality and incidence of delayed encephalopathy were compared between the two groups.Results All the GCS scores the first, second and third day after treatment in the study group were higher than that in the control group(P<0.05).The coma time of the study group(16.74±6.57 h) was lower than that of the control group(22.19±7.03 h)(P<0.05). The mortality rate of the study group was 1.64%, lower than that of the control group(6.56%)(P>0.05). The incidence of the delayed encephalopathy was 18.03%, which was lower than 40.98% of the control group(P<0.05). The cure rate of the study group was 45.90%, and the total effective rate was 85.24%, which were better than 26.23% and 65.57% of the control group(P<0.05).Conclusion Mild hypothermia combined with butylphthalide in the treatment of severe acute carbon monoxide poisoning brain damage could improve GCS score, shorten coma time and reduce the incidence of delayed encephalopathy. It could improve the treatment effect and quality of life of patients.

关 键 词：重度一氧化碳中毒 脑损害 亚低温 丁苯酞 

分 类 号：R595.1[医药卫生—内科学]