动态脉压指数与老年高血压合并糖尿病患者颈动脉硬化的相关性研究  

Correlation between dynamic pulse pressure index and carotid arteriosclerosis in elderly patients with hypertension and diabetes

作　　者：陈娟 王耀玲 CHEN Juan;WANG Yaoling(Department of Geriatrics,Xiangtan First People's Hospital,Xiangtan,Hunan 411100,China;Department of Internal Medicine,Wensu County People's Hospital,Aksu,Xinjiang 843100,China)

机构地区：[1]湘潭市第一人民医院老年医学科,湖南湘潭411100 [2]温宿县人民医院内科,新疆温宿843100

出　　处：《现代医药卫生》2020年第1期22-24,28,共4页Journal of Modern Medicine & Health

摘　　要：目的探讨老年原发性高血压合并2型糖尿病患者动态脉压指数(PPI)与颈动脉硬化的关系。方法收集2018年1-12月在湘潭市第一人民医院住院的老年原发性高血压、原发性高血压合并2型糖尿病患者共197例,据诊断分为原发性高血压合并糖尿病组(病例组,109例)及原发性高血压组(对照组,88例);根据糖化血红蛋白(HbA1c)水平,将病例组再分为A组(HbA1c<7.0%)、B组(HbA1c≥7.0%);分析病例组PPI与颈动脉硬化的关系。结果病例组的年龄、体重指数(BMI)、同型半胱氨酸(Hcy)、尿酸(UA)、肌酐(CR)、C反应蛋白(CRP)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)与对照组比较差异均无统计学意义(P>0.05),2组HbA1c、血清总胆固醇(CHOL)、内中膜厚度(IMT)、24 h动态脉压指数(24 hPPI)、夜动态脉压指数(nPPI)、昼动态脉压指数(dPPI)比较差异均有统计学意义(P<0.05)。A组IMT、24 hPPI、nPPI、dPPI水平B组比较差异有统计学意义(P<0.05),2组间CHOL水平比较差异无统计学意义(P>0.05)。病例组中IMT与24 hPPI、HbA1c、Hcy间存在相关性。结论老年原发性高血压合并2型糖尿病患者的PPI可评估颈动脉硬化。Objective To investigate the relationship between dynamic pulse pressure index(PPI)and carotid atherosclerosis in elderly patients with essential hypertension and type 2 diabetes.Methods A total of 197 elderly patients with essential hypertension and essential hypertension with type 2 diabetes who were hospitalized from January to December 2018 were collected.According to the diagnosis,patients were divided into the essential hypertension and diabetes group(case group)and the essential hypertension and diabetes group(control group).According to the level of glycated hemoglobin(HbA1c),the case group was further divided into group A(HbA1c<7.0%)and group B(HbA1c≥7.0%).The relationship between PPI and carotid arteriosclerosis was analyzed.Results There was no significant difference in age,body mass index(BMI),homocysteine(Hcy),uric acid(UA),creatinine(Cr),C-reactive protein(CRP),triacylglycerol(TG),low density lipoprotein cholesterol(LDL-C)between the two groups(P>0.05).HbA1c,serum total cholesterol(CHOL),intima-media thickness(IMT),24-hour dynamic pulse pressure index(24 hPPI),nocturnal dynamic pulse pressure index(nPPI),and diurnal dynamic pulse pressure index(dPPI)were different in the two groups Statistical significance(P<0.05).The IMT,24 hPPI,nPPI,and dPPI levels in group A were significantly different from those in group B(P<0.05).There was no significant difference in CHOL levels between the two groups(P>0.05).There was a correlation between IMT and 24 hPPI,HbA1c,Hcy in the case group.Conclusion Carotid arteriosclerosis can be assessed by PPI in elderly patients with essential hypertension and type 2 diabetes.

关 键 词：动态脉压指数 颈动脉硬化 原发性高血压 2型糖尿病 老年病 

分 类 号：R544[医药卫生—心血管疾病]