银杏叶胶囊联合尼可地尔治疗冠心病心绞痛临床研究  

Clinical Study of Ginkgo Leaf Capsule and Nicorandil in Treatment of Patients With Angina Pectoris of Coronary Heart Disease

作　　者：杨爱华 YANG Aihua(Pharmaceutical Department,Zhijiang Hospital of Traditional Chinese Medicine,Zhijiang Hubei 510170,China)

机构地区：[1]枝江市中医医院药剂科

出　　处：《中国继续医学教育》2020年第1期147-149,共3页China Continuing Medical Education

摘　　要：目的探寻银杏叶胶囊联合尼可地尔治疗冠心病心绞痛对血清炎性因子和氧化应激指标的影响。方法将本院2017年2月—2018年1月期间收治的210例冠心病心绞痛患者纳入观察对象,通过随机数字表法分成两组,对照组105例采用尼可地尔片,观察组105例则采用银杏叶胶囊联合尼可地尔。对两组患者的评估效果,血清炎性因子,氧化应激指标,副作用的变化情况进行比较。结果(1)观察组临床总有效率显著优于对照组(97.14%vs.85.71%)(P<0.05);(2)经过治疗后,观察组的IL-6、TNF-α、CRP、MDA水平低于对照组,且SOD水平显著升高(P<0.05)。(3)两组患者副作用发生率比较具有统计学意义(P<0.05)。结论对冠心病心绞痛患者给予银杏叶胶囊联合尼可地尔治疗可以抑制炎症反应,并调控氧化应激水平,从而提高临床疗效,且安全性良好。Objective To explore the effects of Ginkgo biloba capsule combined with nicorandil on serum inflammatory factors and oxidative stress index in patients with angina pectoris of coronary heart disease.Methods 210 patients with coronary heart disease and angina pectoris admitted to our hospital from February 2017 to January 2018 were included in the observation.Two groups were divided by random number table.105 cases in the control group were treated with nicorandil tablets.105 cases in the observation group were treated with Ginkgo biloba capsule combined with nicorandil.The evaluation effect,serum inflammatory factors,oxidative stress indicators and side effects of the two groups were compared.Results(1)The total clinical effective rate of the observation group was significantly better than that of the control group(97.14%vs.85.71%)(P<0.05).(2)After treatment,the levels of IL-6,TNF-a,CRP and MDA in the observation group were significantly lower than those in the control group,and the levels of SOD were significantly higher(P<0.05).(3)The incidence of side effects between the two groups was statistically significant(P<0.05).Conclusion Ginkgo biloba capsule combined with nicorandil can inhibit inflammation in patients with coronary heart disease and angina pectoris.It also regulates the level of oxidative stress.In order to improve the clinical efficacy,And the safety is good.

关 键 词：冠心病心绞痛 银杏叶胶囊 尼可地尔 血清炎性因子 氧化应激 副作用 

分 类 号：R541[医药卫生—心血管疾病]