特发性肺纤维化患者血清HIF-1α、TGF-β1的表达及临床意义  

Expression and clinical significance of serum hypoxia-inducible factor-1αand transforming growth factor-β1 in patients with idiopathic pulmonary fibrosis

作　　者：王源 代文静[1] 高瑕 李万成[1] Wang Yuan;Dai Wenjing;Gao Xia;Li Wancheng(Department of Respiratory Medicine,the First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China)

机构地区：[1]成都医学院第一附属医院呼吸科,610500

出　　处：《国际呼吸杂志》2019年第24期1848-1852,共5页International Journal of Respiration

基　　金：国家临床重点专科建设培育科室专项科研项目(CYFY2018GLPHX01)。

摘　　要：目的探讨特发性肺纤维化(IPF)患者血清缺氧诱导因子1α(HIF-1α)、转化生长因子β1(TGF-β1)的变化及意义。方法选择2018年4月至2019年4月成都医学院第一附属医院呼吸科诊治的IPF患者28例为IPF组,选择同期行常规体检的健康者28名为对照组。采用酶联免疫吸附试验检测IPF患者及对照组血清HIF-1α、TGF-β1的水平;并与肺功能、呼吸困难评分、高分辨率CT评分进行相关性分析。结果与对照组比较,IPF组患者血清HIF-1α、TGF-β1水平升高(P值均<0.05)。IPF患者血清HIF-1α、TGF-β1水平分别与用力肺活量、肺总量、第1秒用力呼气容积占预计值百分比、肺一氧化碳弥散量占预计值百分比呈负相关(P值均<0.05),与改良英国医学研究委员会呼吸困难量表评分、胸部高分辨率CT评分呈正相关(P值均<0.05)。结论血清HIF-1α、TGF-β1水平可作为判断IPF病情严重程度、评估治疗效果的指标。Objective To investigate the changes and significance of serum hypoxia-inducible factor-1α(HIF-1α)and transforming growth factor-β1(TGF-β1)in patients with idiopathic pulmonary fibrosis(IPF).Methods Twenty-eight patients with IPF who were diagnosed and treated in the Department of Respiratory Medicine,the First Affiliated Hospital of Chengdu Medical College from April 2018 to April 2019 were selected as IPF group.28 healthy subjects who underwent routine physical examination at the same time were selected as the control group.The levels of serum HIF-1αand TGF-β1 in IPF group and control group were detected by enzyme linked immunosorbent assay.Correlation analysis of serum HIF-1αand TGF-β1 with lung function,dyspnea score and high resolution computed tomography score was performed.Results Compared with the control group,the levels of serum HIF-1αand TGF-β1 were significantly increased in the IPF group(all P<0.05).The levels of serum HIF-1αand TGF-β1 in patients with IPF were negatively correlated with forced vital capacity,total lung capacity,percentage of forced expiratory volume in the first second in the expected value,and percentage of carbon monoxide diffusing capacity in the expected value(all P<0.05),and positively correlated with modified British medical research council score and chest high resolution computed tomography score(all P<0.05).Conclusions The levels of serum HIF-1αand TGF-β1 can be used as indicators to judge the severity of IPF and evaluate the therapeutic effect.

关 键 词：特发性肺纤维化 缺氧诱导因子1 Α亚基 转化生长因子Β1 

分 类 号：R56[医药卫生—呼吸系统]