Physically Cross-linked Hydrogels with Excellent Self-healing, Moldability, Antibacterial Activities and Adjustable Mechanical Properties  

作　　者：HE Guanghua CAO Jilong WANG Cheng FAN Lihong YIN Yihua CAI Weiquan TAO Shengxiang 何广华;CAO Jilong;WANG Cheng;FAN Lihong;YIN Yihua;CAI Weiquan;陶圣祥(School of Chemistry,Chemical Engineering and Life Sciences,Wuhan University of Technology,Wuhan 430070,China;Department of Orthopedics,Zhongnan Hospital of Wuhan University,Wuhan 430070,China)

机构地区：[1]School of Chemistry,Chemical Engineering and Life Sciences,Wuhan University of Technology,Wuhan 430070,China [2]Department of Orthopedics,Zhongnan Hospital of Wuhan University,Wuhan 430070,China

出　　处：《Journal of Wuhan University of Technology(Materials Science)》2019年第6期1484-1494,共11页武汉理工大学学报（材料科学英文版）

基　　金：Funded by the National Natural Science Foundation of China(Nos.51773161,51303145,51373130,and 21975057);the Special Project of Technological Innovation of Hubei Province(No.2019ABA115)

摘　　要：A simple strategy was developed to prepare a tough, self-healing, antibacterial and moldable hydrogel by introducing the natural polyphenolic compound tannic acid(TA) as a cross-linking center for hydrogen bonds. Polyvinyl alcohol(PVA)-TA hydrogel was prepared by physical mixing using PVA as a main component and TA as a cross-linker. There were two types of physical cross linking bonds in the PVA-TA hydrogel network, which were weaker hydrogen bonds between PVA molecular chains and stronger hydrogen bonds between PVA and TA molecules. The mechanical properties and self-healing ability could be adjusted by changing the contents of PVA and TA. The hydrogel possessed not only high mechanical strength(305 kPa tensile strength and 864 kPa compressive strength), moldability and excellent self-healing properties(95% selfhealing efficiency) but also good antibacterial abilities against S. aureus and E. coli. In addition, after soaking the dried hydrogel in 90 ℃ deionized water for 4 h, they could also regain their self-healing ability to a certain extent. The hydrogels have potential applications in the biomedical fields.A simple strategy was developed to prepare a tough, self-healing, antibacterial and moldable hydrogel by introducing the natural polyphenolic compound tannic acid(TA) as a cross-linking center for hydrogen bonds. Polyvinyl alcohol(PVA)-TA hydrogel was prepared by physical mixing using PVA as a main component and TA as a cross-linker. There were two types of physical cross linking bonds in the PVA-TA hydrogel network, which were weaker hydrogen bonds between PVA molecular chains and stronger hydrogen bonds between PVA and TA molecules. The mechanical properties and self-healing ability could be adjusted by changing the contents of PVA and TA. The hydrogel possessed not only high mechanical strength(305 kPa tensile strength and 864 kPa compressive strength), moldability and excellent self-healing properties(95% selfhealing efficiency) but also good antibacterial abilities against S. aureus and E. coli. In addition, after soaking the dried hydrogel in 90 ℃ deionized water for 4 h, they could also regain their self-healing ability to a certain extent. The hydrogels have potential applications in the biomedical fields.

关 键 词：TOUGHNESS SELF-HEALING moldability antibacterial swelling-resistant 

分 类 号：R318.08[医药卫生—生物医学工程] O648.17[医药卫生—基础医学]