柴胡龙骨牡蛎汤联合西医常规疗法治疗躯体性焦虑症临床研究  

Clinical study of Chaihu-Longgu-Muli decotion combined with western medicine in the treatment of somatic anxiety disorder

作　　者：李艳[1] 金敏[2] 杨羽 Li Yan;Jin Min;Yang Yu(Psychological Counseling Clinic,Rizhao Traditional Chinese Medicine Hospital,Rizhao 276800,China;Department of Pediatric,Rizhao Traditional Chinese Medicine Hospital,Rizhao 276800,China;Department of Neurosurgery,Rizhao Traditional Chinese Medicine Hospital,Rizhao 276800,China)

机构地区：[1]山东省日照市中医医院心理咨询门诊,276800 [2]山东省日照市中医医院儿科,276800 [3]山东省日照市中医医院神经外科,276800

出　　处：《国际中医中药杂志》2019年第12期1314-1317,共4页International Journal of Traditional Chinese Medicine

摘　　要：目的评价柴胡龙骨牡蛎汤联合西医常规疗法治疗躯体性焦虑症的疗效。方法将符合入选标准的93例躯体性焦虑症患者采用随机数字表法分为对照组46例和研究组47例。对照组采用西医常规疗法治疗,研究组在对照组基础上加用柴胡龙骨牡蛎汤治疗。2组均治疗4周。分别于治疗前后进行中医证候评分,采用匹兹堡睡眠质量指数(Pittsburgh Sleep Quality Index,PSQI)评估睡眠质量,采用焦虑自评量表(Self-rating Anxiety Scale,SAS)评估焦虑程度;记录不良反应,评价临床疗效。结果研究组总有效率为93.6%(44/47)、对照组为67.4%(31/46),2组比较差异有统计学意义(χ^2=10.244,P=0.001)。研究组治疗后失眠、肢体怕冷、心悸心慌、肢体倦怠、肢体疼痛评分均低于对照组(t值分别为4.190、4.707、4.714、3.686、7.070,P值均<0.01)。治疗后,研究组PSQI[(9.4±3.2)分比(13.8±3.8)分,t=6.243]、SAS[(48.7±13.7)分比(58.1±12.9)分,t=3.411]评分均低于对照组(P<0.01)。治疗期间,对照组不良反应发生率为19.6%(9/46)、研究组为4.3%(2/47),2组比较差异有统计学意义(χ^2=5.225,P=0.022)。结论柴胡龙骨牡蛎汤联合西医常规疗法可有效改善躯体性焦虑症患者中医证候、睡眠质量及焦虑情绪,减少不良反应,提高临床疗效。Objective To evaluate the therapeutic effect of Chaihu-Longgu-Muli decotion combined with western medicine in the treatment of somatic anxiety disorder.Methods A total of 93 patients with somatic anxiety were divided into control group(46 cases)and study group(47 cases)according to random number table method.The control group was treated with conventional western medicine.The study group was treated with Chaihu-Longgu-Muli decotion on the basis of the control group.The two groups were treated for 4 weeks.Before and after treatment,TCM syndrome scores were conducted.The Pittsburgh Sleep Quality Index(PSQI)was used to evaluate sleep quality.The Self-rating Anxiety Scale(SAS)was used to evaluate anxiety.The adverse reaction was recorded and clinical efficacy was evaluated.Results The total effective rate of the study group was 93.62%(44/47),67.39%(31/46)of the control group,and the difference was statistically significant between the two groups(χ^2=10.244,P=0.001).After treatment,insomnia,limb chills,palpitation,limb burnout,limb pain scores in the study group were significantly lower than those of the control group(t values were 4.190,4.707,4.714,3.686,7.070,respectively,all Ps<0.01).After treatment,the scores of PSQI(9.4±3.2 vs.13.8±3.8,t=6.045)and SAS(48.7±13.7 vs.58.1±12.9,t=3.405)in the study group were significantly lower than those in the control group(P<0.01).During the treatment,the incidence of adverse reactions was 19.6%(9/46)in the control group and 4.3%(2/47)in the study group.The difference between the two groups was statistically significant(χ^2=5.225,P=0.022).Conclusions The Chaihu-Longgu-Muli decotion combined with western medicine can improve the symptoms of traditional Chinese medicine,sleep quality and anxiety of patients with somatic anxiety,reduce adverse reactions and improve the clinical efficacy.

关 键 词：焦虑症 抗焦虑药(中药) 柴胡龙骨牡蛎汤 中西医结合疗法 

分 类 号：R47[医药卫生—护理学]