喜炎平注射液与盐酸小檗碱联用对小儿轮状病毒肠炎疗效及对外周血中性粒细胞的影响  

Effect of Xiyanping Injection combined with berberine hydrochloride on children with rotavirus enteritis and peripheral blood neutrophils

作　　者：青艳萍 张晓明[2] 周博[3] QING Yanping;ZHANG Xiaoming;ZHOU Bo(Department of Quality Control,Ankang Traditional Chinese Medicine Hospital,Ankang 725000,China;Department of Pharmacy,Affiliated Hospital of Shangluo Vocational and Technical College,Shangluo 726000,China;Department of Pediatrics,Affiliated Hospital of Shangluo Vocational and Technical College,Shangluo 726000,China)

机构地区：[1]安康市中医医院质控科,陕西安康725000 [2]商洛职业技术学院附属医院药剂科,陕西商洛726000 [3]商洛职业技术学院附属医院儿科,陕西商洛726000

出　　处：《药物评价研究》2019年第12期2414-2417,共4页Drug Evaluation Research

基　　金：陕西省卫生厅科研基金项目(2015JM40236)

摘　　要：目的探讨喜炎平注射液与盐酸小檗碱片联用对小儿轮状病毒肠炎的疗效以及对外周血中性粒细胞功能的影响。方法选取2015年8月-2018年9月安康市中医医院收治的轮状病毒性肠炎患儿99例,根据患儿入院先后顺序分为两组。对照组50例,在常规治疗的基础上加用盐酸小檗碱片保留灌肠治疗;观察组49例,在对照组的基础上给予喜炎平注射液治疗。比较两组患儿的临床治疗效果、临床症状缓解时间、轮状病毒转阴时间和中性粒细胞功能。结果治疗后,观察组临床总有效率为91.84%,显著高于对照组的76.00%(P<0.05)。治疗后,观察组患者发热、呕吐、腹泻、腹胀腹痛缓解时间和轮状病毒转阴时间均显著低于对照组(P<0.05)。治疗后,观察组的细胞活化率和刺激指数显著高于对照组(P<0.05)。结论喜炎平注射液与盐酸小檗碱片联用可显著提高轮状病毒肠炎患儿临床治疗效果,快速缓解临床症状,缩短轮状病毒转阴时间,并可提高中性粒细胞功能,值得临床借鉴。Objective To investigate the effect of Xiyanping Injection combined with Berberine Hydrochloride Tablets on rotavirus enteritis and peripheral blood neutrophil function. Methods A total of 99 children with rotavirus enteritis admitted to Ankang Traditional Chinese Medicine Hospital from August 2015 to September 2018 were enrolled. According to the order of admission, the patients were divided into two groups. In the control group, 50 patients were treated with Berberine Hydrochloride Tablets retention enema on the basis of routine treatment. 49 patients in the observation group were treated with Xiyanping Injection on the basis of the control group. The clinical treatment effects in two groups were compared. Clinical symptom relief time, rotavirus negative time,and neutrophil function were compared. Results After treatment, the total clinical effective rate of the observation group was91.84%, which was significantly higher than 76.00% of the control group(P < 0.05). After treatment, the time of fever, vomiting,diarrhea, abdominal distension and abdominal decay, and rotavirus negative time in the observation group were significantly lower than those in the control group(P < 0.05). After treatment, the cell activation rate and stimulation index in the observation group were significantly higher than those in the control group(P < 0.05). Conclusion Xiyanping Injection combined with Berberine Hydrochloride Tablets can significantly improve the clinical treatment effect of children with rotavirus enteritis, rapidly relieve clinical symptoms, shorten rotavirus conversion time, and improve neutrophil function, which is worthy of clinical reference.

关 键 词：喜炎平注射液 盐酸小檗碱片 小儿轮状病毒肠炎 中性粒细胞功能 

分 类 号：R985[医药卫生—药品]