妊娠合并急性胰腺炎对母婴结局的影响  

Analysis of the effect of pregnancy complicated with acute pancreatitis on maternal and infant outcomes

作　　者：许仁美 柏永明 童武华[1] Xu Renmei;Bai Yongming;Tong Wahua(Department of Intensive Care Unit,the Maternal and Child Health Care Hospital of Jiaxing,Jiaxing,Zhejiang 314000,China;Department of Internal Medicine,Wangdian Peopl's Hospital of Jiaxing,Jiwcing,Zhejiang 314011,China)

机构地区：[1]嘉兴市妇幼保健院重症医学科,浙江省314000 [2]嘉兴市王店人民医院内科,浙江省314011

出　　处：《中国基层医药》2019年第24期2976-2979,共4页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨妊娠合并急性胰腺炎对母婴结局的影响,为临床干预方案制定提供参考依据.方法 选取嘉兴市妇幼保健院2012年1月至2018年1月收治的妊娠合并急性胰腺炎患者62例作为研究对象,均为单胎,根据急性胰腺炎发病原因和病情严重程度对患者进行分组.分析妊娠结局和新生儿情况.结果 62例妊娠合并急性胰腺炎患者中,其中足月分娩者为40例(64.52%),早产20例(32.26%),胎死宫内2例(3.22%),纳入此次研究的新生儿为60例.不同发病原因早产儿比例和新生儿出生体质量、新生儿疾病构成比例比较,差异均无统计学意义(其中早产儿F=0.691,P=0.352;出生体质量F=1.042,P=0.382;高胆红素血症F=1.382,P=0.521;呼吸窘迫综合征F=0.496,P=0.584;低血糖F=3.102,P=0.165;感染性疾病F=0.895,P=0.124;颅内出血F=0.004,P=0.932);而终止妊娠率比较(胆源性占57.69%、高脂血症性占82.14%、其他占25.00%),差异有统计学意义( F=12.541,P=0.000),且高脂血症性组比率最高(82.14%).中度妊娠合并急性胰腺炎组早产儿比例最高(75.0%),且出生体质量最低(F=8.142、4.581, P=0.000、0.001 );各不同病情程度间终止妊娠比例比较(轻度占 12.19%、中度占 75.00%、重度占69.23%),差异无统计学意义(F=1.251,P=0.4125).轻度妊娠合并急性胰腺炎组发生颅内出血(0.00%)和新生儿呼吸窘迫综合征(2.44%)及感染性疾病率(4.88%)最低( F=8.641、7.362、6.982,P=0.000、0.000、0.000).结论 妊娠合并急性胰腺炎对患者可造成不良妊娠结局,且影响新生儿健康,随着患者病情的加重,其不良结局将会更为严重.Objective To explore the effect of pregnancy with acute pancreatitis on maternal and infant outcomes,thus to provide reference for the development of clinical intervention programs .Methods From January 2012 to January 2018,62 pregnant patients with acute pancreatitis in the Maternal and Child Health Hospital of Jiaxing were selected as study objects.All of them were singletons.The patients were grouped according to the cause of acute pancreatitis and the severity of the disease.The pregnancy outcomes and neonatal conditions were analyzed. Results Of 62 patients with acute pancreatitis ,40 cases (64.52%) had full-term delivery,20 cases (32.26%) had premature delivery,and 2 cases(3.22%) had intrauterine fetal death.The newborns included in the study were 60 cases.There were no statistically significant differences in the proportion of premature infants between different morbidity factors,neonatal birth weight and neonatal disease composition ( the premature infants:F =0.691, P =0.352;birth weight:F=1.042,P=0.382;biliary erythremia:F=1.382,P=0.521;respiratory distress syndrome:F=0.496,P=0.584;hypoglycemia:F=3.102,P=0.165;infectious disease:F=0.895,P=0.124;intracranial hemorrhage:F=0.004,P=0.932).The difference of termination pregnancy rate was statistically significant (biliary 57.69%,hyperlipidemia 82.14%,other 25.00%) (F=12.541,P=0.000),and the rate of the lipemia group was the highest (82.14%).The proportion of premature infants with moderate pregnancy and acute pancreatitis was the highest (75.0%),and the birth weight was the lowest ( F=8.142,4.581,P=0.000,0.001).The proportion of termination of pregnancy among different degrees of disease had no statistically significant difference (mild 12.19%, moderate 75.0%,and severe 69.23%) (F=1.251,P=0.4125).The intracranial hemorrhage (0.00%),neonatal respiratory distress syndrome (2.44%) and infectious disease rate (4.88%) were the lowest in mild pregnancy with acute pancreatitis (F=8.641,7.362,6.982,P=0.000,0.000,0.000).Conclusion Pregnancy with acute pancre-atitis ca

关 键 词：妊娠结局 胰腺炎 婴儿 早产 妊娠并发症 呼吸窘迫综合征 新生儿 

分 类 号：R71[医药卫生—妇产科学]