复方丹参注射液对妊娠期高血压疾病患者氧化应激及分娩并发症的影响  

Influence of compound salvia injection on oxidative stress and complications in patients with gestational hypertension

作　　者：李宁[1] 郭文玲[1] 马建林[2] 陈秀平[3] 王佃卫[1] Li Ning;Guo Wenling;Ma Jianlin;Chen Xiuping;Wang Dianwei(Department of Obstetrics,Binzhou Central Hospital,Binzhou,Shandong 251100,China;Department of Emergency,Binzhou Central Hospital,Binzhou,Shandong 251100,China;Department of Ultrasound,Binzhoa Central Hospital,Binzhou,Shandong 251700,China)

机构地区：[1]滨州市中心医院产科,山东省251700 [2]滨州市中心医院急诊科,山东省251700 [3]滨州市中心医院超声科,山东省251700

出　　处：《中国基层医药》2019年第24期2988-2992,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨复方丹参注射液对妊娠期高血压疾病患者氧化应激及分娩并发症的影响.方法 选取滨州市中心医院2015年8月至2017年12月收治的妊娠期高血压疾病患者140例为研究对象,采用随机数字表法将其分为研究组与对照组各70例,对照组患者采用常规治疗,研究组联合复方丹参注射液治疗,治疗后比较两组患者超氧化物歧化酶( SOD)、丙二醛( MDA)、一氧化氮( NO)、高迁移率蛋白-1 (HMGB1)、半胱氨酸蛋白酶抑制剂C(Cys C)、肿瘤坏死因子α(TNF-α)、超敏C-反应蛋白( hs-CRP)、血压及并发症.结果 治疗后研究组NO[(942.58 ±80.69)mmol/L比(734.51 ±78.63)mmol/L]与SOD[(124.65 ± 23.81)U/mL 比( 90.64 ±24.13) U/mL]水平均高于对照组, MAD [(10.47 ±3.14) nmol/L 比( 15.82 ± 3.32)nmol/L]水平较对照组低,差异均有统计学意义(t=15.451、8.394、9.795,均P<0.05).治疗后研究组HMGB1[(1.81 ±0.43)mg/L比(3.89 ±0.65 ) mg/L]、Cys C [(1.04 ±0.18) mg/L比(1.42 ±0.27) mg/L]、TNF-α[(15.09 ±3.14)ng/L比(21.45 ±4.78)ng/L]及hs-CRP[(3.04 ±0.81)mg/L比(6.32 ±1.45)mg/L]水平均较对照组低,差异均有统计学意义(t=22.329、9.798、9.304、16.523,均P<0.05).治疗后研究组收缩压[(131.25 ±5.74)mmHg比(139.61 ±5.59)mmHg]与舒张压[(85.23 ±5.07)mmHg比(90.43 ±5.81)mmHg]均较对照组低,差异均有统计学意义(t=8.730、5.642,均P<0.05).研究组剖宫产率(61.43%比87.14%)及宫内窘迫发生率(1.43%比11.43%)均低于对照组,差异均有统计学意义( χ^2 =12.115、5.818,均P<0.05).结论 复方丹参注射液对妊娠期高血压疾病患者氧化应激及炎性反应控制效果显著,有利于减少分娩并发症发生.Objective To investigate the influence of compound salvia injection on oxidative stress and complications in patients with gestational hypertension.Methods From August 2015 to Fabuary 2017,140 patients with gestational hypertension in Binzhou Central Hospital were selected as study objects ,and randomly divided into control group and research group according to the digital table ,with 70 cases in each group.The control group was treated with routine treatment ,the research group was given routine treatment combined with compound salvia injec-tion.After treatment,SOD,MDA,NO,HMGB1,Cys C,hs-CRP,TNF-α,blood pressure and complications between the two groups were compared.Results After treatment,the levels of NO[(942.58 ±80.69)mmol/L vs.(734.51 ± 78.63)mmol/L] and SOD[(124.65 ±23.81)U/mL vs.(90.64 ±24.13)U/mL] in the research group were higher than those in the control group ,and the MAD level [(10.47 ±3.14) nmol/L vs.(15.82 ±3.32) nmol/L] in the research group was lower than that in the control group ,the difference were statistically significant between the two groups(t=15.451,8.394,9.795,all P<0.05).After treatment,the levels of HMGB1 [(1.81 ±0.43) mg/L vs. (3.89 ±0.65)mg/L],Cys C[(1.04 ±0.18)mg/L vs.(1.42 ±0.27) mg/L],TNF-α[(15.09 ±3.14) ng/L vs. (21.45 ±4.78) ng/L] and hs-CRP[(3.04 ±0.81) mg/L vs.(6.32 ±1.45) mg/L] in the research group were lower than those in the control group ,the differences were statistically significant (t=22.329,9.798,9.304,16.523, all P<0.05).After treatment,the systolic blood pressure[(131.25 ±5.74)mmHg vs.(139.61 ±5.59)mmHg] and diastolic blood pressure[(85.23 ±5.07)mmHg vs.(90.43 ±5.81) mmHg] in the research group were lower than those in the control group(t=8.730,5.642,all P<0.05).The cesarean section rate (61.43% vs.87.14%) and intrauterine distress rate(1.43%vs.11.43%) in the research group were lower than those in the control group (χ^2 =12.115,5.818,all P<0.05).Conclusion Compound salvia miltiorrhiza injection has significant control effect on oxidative stress

关 键 词：高血压 妊娠性 氧化性应激 炎症 妊娠并发症 分娩 血压 妊娠结局 复方丹参注射液 

分 类 号：R54[医药卫生—心血管疾病]