根除幽门螺旋杆菌影响因素的研究进展  

Advances in the research of factors impacting on helicobacter pylori eradication

作　　者：刘梦真 刘群[1] LIU Meng-zhen;LIU Qun(Department of Gastroenterology,Tianyou Hospital,Wuhan University of Science and Technology,WuHan 430000,Hubei,China)

机构地区：[1]武汉科技大学附属天佑医院消化内科

出　　处：《医学研究生学报》2019年第12期1339-1344,共6页Journal of Medical Postgraduates

摘　　要：幽门螺旋杆菌可以通过口-口、粪-口途径进行传播,且与慢性胃炎、消化性溃疡和胃腺癌等胃肠道疾病的发展有关,世界目前幽门螺旋杆菌根除率并无明显提高,甚至有下降趋势。如何提高幽门螺旋杆菌的根除率是我们临床医师亟待解决的问题。文章结合国内外文献以及临床新进展,从Hp相关因素、药物因素(PPI的不同、抗生素的耐药)、患者因素(患者生活习性、患者依从性、患者年龄划分、胃部疾病)、其他因素(根除幽门螺旋杆菌治疗方案不同、胃内幽门螺旋杆菌定植密度、)、辅助治疗(益生菌、25-OH维生素D对根除幽门螺杆菌的影响)、疫苗等多方面综述,以期对临床治疗提供一定的帮助。In the eradication of Helicobacter pylori,China has carried out more than 30 years of efforts.The treatment plan has evolved,but the eradication rate has not increased significantly,and even has a downward trend.How to improve the eradication rate of Helicobacter pylori is an urgent problem for our clinicians.Combined domestic and foreign literature with new clinical progress,this paper reviews from many aspects,such as Hp related factors,drug factors,patient factors,other factors,and many other as-pects,in order to provide some help for clinical treatment.

关 键 词：幽门螺旋杆菌 Hp毒力因子 影响因素 HP根除率 HP疫苗 

分 类 号：R37[医药卫生—病原生物学]