应用Tei指数评估妊娠期肝内胆汁淤积症孕妇胎儿心功能的临床研究  

A Clinical Study of Using Tei Index to Evaluate Fetal Cardiac Function in Pregnant Women with Intrahepatic Cholestasis of Pregnancy

作　　者：苏林丘[1] 郭鹊晖[1] 许荣[1] 林晴[1] 游涛[1] SU Lin-qiu;GUO Que-hui;XU Rong;LIN Qing;YOU Tao(Department of Ultrasound,the Second People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Fuzhou,Fujian Province,350003 China)

机构地区：[1]福建中医药大学附属第二人民医院超声科

出　　处：《中外医疗》2019年第34期62-64,共3页China & Foreign Medical Treatment

摘　　要：目的应用Tei指数评估妊娠期肝内胆汁淤积症孕妇胎儿的整体心功能,为临床诊治ICP提供参考。方法方便选取2017年6月—2019年1月该院ICP孕妇105例为研究对象,根据孕妇血清总胆汁酸水平分为A、B、C 3组,A组为重度ICP孕妇组(32例),孕妇血清总胆汁酸水平≥80μmol/L;B组为中度ICP孕妇组(35例),孕妇血清总胆汁酸水平≥40μmol/L、<80μmol/L;C组为轻度ICP孕妇组(38例),孕妇血清总胆汁酸水平≥10μmol/L、<40μmol/L;同时选择相同孕周的正常妊娠孕妇(50名)作为对照组(D组),孕妇血清总胆汁酸水平<10μmol/L。应用超声心动图测量胎儿的LVFS、LVEF、RVPCA及左、右心室的Tei指数,并进行比较分析。结果4组胎儿LVFS均>28%,LVEF均>58%,RVPCA均>42%,组间比较差异无统计学意义(P>0.05);A、B、C、D 4组胎儿左心室Tei指数分别为(0.67±0.05)、(0.55±0.05)、(0.38±0.05)、(0.36±0.04);A、B、C、D 4组胎儿右心室Tei指数分别为(0.66±0.06)、(0.57±0.05)、(0.39±0.04)、(0.38±0.03);A组和B组左、右心室Tei指数明显高于C组和D组,差异有统计学意义(P<0.05);A组左、右心室Tei指数亦高于B组,差异有统计学意义(P<0.05);C组左、右心室Tei指数与D组相比,差异无统计学意义(P>0.05)。结论Tei指数可以早期、准确、有效地评估中、重度ICP孕妇胎儿的左、右心室的整体心功能。Objective To evaluate the fetal cardiac function in pregnant women with intrahepatic cholestasis of pregnancy by using Tei index,so as to provide reference for clinical diagnosis and treatment of ICP.Methods From June 2017 to January 2019,convienient 105 ICP pregnant women in the hospital were selected as subjects.According to the serum total bile acid level of pregnant women,they were divided into three groups:A,B and C.Group A was severe ICP pregnant women(32 cases),pregnant women.Serum total bile acid level≥80μmol/L;group B was moderate ICP pregnant women group(35 cases),pregnant women serum total bile acid level≥40μmol/L,<80μmol/L;group C was mild ICP pregnant women group 38 cases The serum total bile acid level of pregnant women was≥10μmol/L,<40μmol/L;at the same time,the normal pregnant women(50 cases)with the same gestational age were selected as the control group(D group),and the serum total bile acid level of pregnant women was<10μmol/L.Echocardiography was used to measure fetal LVFS,LVEF,RVPCA and Tei index of left and right ventricles,and comparative analysis was performed.Results LVFS>28%,LVEF>58%,and RVPCA>42%in all the four groups,and there was no statistically significant difference between the groups(P>0.05).The Tei index of the left ventricle of fetuses in group A,B,C and D was(0.67±0.05),(0.55±0.05),(0.38±0.05)and(0.36±0.04),respectively.The Tei index of right ventricle of fetuses in group A,B,C and D was(0.66±0.06),(0.57±0.05),(0.39±0.04),(0.38±0.03),respectively.Tei index of left and right ventricle in group A and group B was significantly higher than that in group C and group D,with statistically significant difference(P<0.05).The Tei index of left and right ventricle in group A was higher than that in group B,and the difference was statistically significant(P<0.05).Compared with group D,group C showed no statistically significant difference in Tei index of left and right ventricle(P>0.05).Conclusion Tei index can be used to evaluate the global cardiac function of the left

关 键 词：妊娠期肝内胆汁淤积症 TEI指数 胎儿心功能 

分 类 号：R5[医药卫生—内科学]