肺炎患儿外周血降钙素原、超敏C反应蛋白、细胞免疫指标变化及意义  

The Changes and Significance of Procalcitonin High-sensitivity C-reactive Protein, and Cellular Immunity in Peripheral Blood of Children with Pneumonia

作　　者：袁婷[1] 张家明[1] 罗潇[1] 邱瑾[1] 曾梦如[1] YUAN Ting;ZHANG Jiaming;LUO Xiao;QIU Jin;ZENG Mengru(Zhanjiang Central People’s Hospital,Zhanjiang 524046,China)

机构地区：[1]湛江中心人民医院

出　　处：《中外医学研究》2019年第34期76-78,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:研究外周血降钙素原、超敏C反应蛋白、细胞免疫指标变化对于肺炎患儿的作用。方法:选择2016年9月-2017年9月笔者所在医院肺炎患儿90例,包括细菌性肺炎、病毒性肺炎、支原体肺炎三种疾病患儿,另外选取30例健康小儿作为对照组,均接受外周血超敏C反应蛋白、降钙素原及细胞免疫指标测定,分析结果。结果:支原体肺炎组、细菌性肺炎组hs-CRP高于对照组,差异有统计学意义(P<0.05);病毒性肺炎组hs-CRP与对照组比较,差异无统计学意义(P>0.05);支原体肺炎组hs-CRP与细菌性肺炎组比较,差异无统计学意义(P>0.05)。支原体肺炎组、细菌性肺炎组、病毒性肺炎组CD3^+、CD4^+、CD4^+/CD8^+低于对照组,CD8^+高于对照组,差异有统计学意义(P<0.05);病毒性肺炎组、支原体肺炎组、细菌性肺炎组的CD3^+、CD4^+、CD8^+、CD4^+/CD8^+比较,差异无统计学意义(P>0.05)。细菌性肺炎组患儿在检测后其PCT、PCT总阳性率高于病毒性肺炎组、支原体肺炎组、对照组,差异有统计学意义(P<0.05)。结论:通过测定外周血超敏C反应蛋白、降钙素原及细胞免疫指标水平,有助于临床肺炎的诊断及鉴别,指导临床治疗方案的选择。Objective:To study the effects of peripheral blood procalcitonin,hypersensitive C-reactive protein and cellular immune index on children with pneumonia.Method:A total of 90 children with pneumonia in our hospital from September 2016 to September 2017,including children with bacterial pneumonia,viral pneumonia and mycoplasmal pneumonia,and 30 healthy children were selected as the control group.The blood hypersensitive C-reactive protein,procalcitonin and cellular immune indicators were measured and analyzed.Result:The hs-CRP in the mycoplasma pneumonia group and the bacterial pneumonia group was significantly higher than that in the control group(P<0.05).There was no significant difference in hs-CRP between the viral pneumonia group and the control group(P>0.05).There was no significant difference in hs-CRP between the mycoplasmal pneumonia group and the bacterial pneumonia group(P>0.05).CD3^+,CD4^+,CD4^+/CD8^+in the mycoplasma pneumonia group,bacterial pneumonia group and viral pneumonia group were lower than the control group,CD8^+was higher than the control group,the difference was statistically significant(P<0.05).There were no significant differences in CD3^+,CD4^+,CD8^+,and CD4^+/CD8^+among the viral pneumonia,bacterial pneumonia group and mycoplasma pneumonia(P>0.05).The total positive rate of PCT and PCT level in bacterial pneumonia group were significantly higher than those in the viral pneumonia group,mycoplasma pneumonia and control group,the differences were statistically significant(P<0.05).Conclusion:By measuring the levels of peripheral blood hypersensitive C-reactive protein,procalcitonin and cellular immune markers.It is helpful for the diagnosis and identification of clinical pneumonia,and guide the choice of clinical treatment options.

关 键 词：肺炎 外周血 超敏C 反应蛋白 降钙素原 细胞免疫指标 

分 类 号：R72[医药卫生—儿科]