系统性红斑狼疮患者血清VCAM-1、sICAM-1水平与病情活动的相关性  

Correlation between the Levels of Serum Vascular Endothelial Cell Adhesion Molecules-1, Soluble Intercellular Adhesion Molecule-1 and Disease Activity in Patients with Systemic Lupus Erythematosus

作　　者：吴文胜[1] WU Wensheng(The Second Hospital of Sanming,Yong’an 366000,China)

机构地区：[1]三明市第二医院

出　　处：《中外医学研究》2019年第34期78-81,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨系统性红斑狼疮(systemic lupus erythematosus,SLE)患者血管内皮细胞黏附分子-1(vascular endothelial cell adhesion molecules-1,VCAM-1)、可溶性细胞间黏附分子-1(soluble intercellular adhesion molecule-1,sICAM-1)水平变化,分析其与SLE病情活动的相关性。方法:纳入2017年6月-2019年6入住笔者所在医院确诊为SLE的患者60例,根据SLE疾病活指数(systemic lupus erythematosus disease activity index,SLEDAI)分成SLE非活动组(n=22)与SLE活动组(n=38),同期健康体检者30例为对照组。收集血白细胞计数(WBC)、中性粒细胞(NEUT)、淋巴细胞计数(LYMT)、血红蛋白(HB)、血小板(PLT)、中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)、白蛋白(ALB)、球蛋白(GLB)、白蛋白/球蛋白比值(AGR)、免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)、补体C3(C3)、补体C4(C4)、24 h尿蛋白定量(24 h UP)、C反应蛋白(CRP)、血沉(ESR),采用酶联免疫吸附试验检测各组VCAM-1、sICAM-1水平。结果:活动组WBC、HB、PLT、NEUT、LYMT、ALB、AGR、C3、C4水平均低于非活动组及对照组,且非活动组均低于对照组,差异均有统计学意义(P<0.01);活动组NLR、PLR、GLB、ESR、CRP、IgG、24 h UP均高于非活动组及对照组,且非活动组均高于对照组,差异均有统计学意义(P<0.01),三组IgA、IgM比较差异无统计学意义(P>0.05)。活动组血清VCAM-1、sICAM-1水平均高于对照组及非活动组,且非活动组均高于对照组,差异均有统计学意义(P<0.01)。SLE患者血清VCAM-1、sICAM-1与SLEDAI、NLR、PLR、ESR、24 h UP均呈正相关,与AGR、C3呈负相关,差异均有统计学意义(P<0.05)。结论:SLE患者血清VCAM-1、sICAM-1水平明显升高,且与SLE病情活动明显相关。Objective:To observe the levels of serum vascular endothelial cell adhesion molecules-1(VCAM-1),soluble intercellular adhesion molecule-1(sICAM-1)in patients with systemic lupus erythematosus(SLE),and analysis correlation between VCAM-1,sICAM-1 and the disease activity of the SLE.Method:From June 2017 to June 2019,60 patients with SLE diagnosed by the author’s hospital were selected for the study.They were divided into non-active group(22 cases)and the active group(38 cases)according to the SLE disease activity index(SLEDAI).Another 30 patients with healthy physical in our hospital during the same period were selected as the control group.The blood cell count(WBC),neutrophil(NEUT),lymphocyte count(LYMT),hemoglobin(HB),platelet(PLT),neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR),albumin(ALB),globulin(GLB),albumin/globulin ratio(AGR),immunoglobulin G(IgG),immunoglobulin A(IgA),immunoglobulin M(IgM),complement C3(C3),complement C4(C4),24-hour urinary protein quantification(24 h UP),C-reactive protein(CRP),erythrocyte sedimentation(ESR)were collected.The VCAM-1 and sICAM-1 levels of two groups were detected by enzyme linked immunosorbent assay.Result:The levels of WBC,HB,PLT,NEUT,LYMT,ALB,AGR,C3,C4 in the active group were lower than those in the non-active group and the control group,and the levels in the non-active group were lower than those in the control group,the differences were statistically significant(P<0.01).The levels of NLR,PLR,GLB,ESR,CRP,IgG,24 h UP in the active group were higher than those in non-active group and control group,and the non-active group was higher than the control group,the differences were statistically significant(P<0.01),but there were no significant differences in IgA,IgM among the three groups(P>0.05).The levels of VCAM-1 and sICAM-1 in the active group were higher than those in the control group and the non-active group,and the non-active group was higher than the control group,the differences were statistically significant(P<0.01).Serum VCAM-1,sICAM-1 was posi

关 键 词：系统性红斑狼疮 血管内皮细胞黏附分子-1 可溶性细胞间黏附分子-1 疾病活动度 相关性 免疫球蛋白 血小板 

分 类 号：R59[医药卫生—内科学]