参附注射液联合持续血液灌流对急性百草枯中毒患者肺功能的影响  

The Effect of Shenfu Injection Combined with Continuous Hemoperfusion on Lung Injury in Patients with Acute Paraquat Poisoning

作　　者：王莎莎 张冰[1] 冯文玉[1] WANG Shasha;ZHANG Bing;FENG Wenyu(Affiliated Hospital of Binzhou Medical College,Binzhou 256600,China)

机构地区：[1]滨州医学院附属医院

出　　处：《中外医学研究》2019年第34期141-143,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析急性百草枯中毒(APP)患者采取参附注射液联合持续血液灌流治疗效果及其对肺损伤的影响。方法:选取2018年1月-2019年1月笔者所在医院接收的78例急性百草枯中毒患者,根据先后入院时间分为两组,对照组(n=39)开展常规药物治疗与持续血液灌流,研究组(n=39)则接受持续血液灌流联合参附注射液,统计各组治疗前后临床指标及肺纤维化发生率。结果:治疗前两组血一氧化氮、Ⅲ型前胶原肽、诱导型一氧化氮合酶比较差异无统计学意义(P>0.05),治疗后研究组均低于对照组,差异均有统计学意义(P<0.05);研究组肺纤维化发生率及治疗总有效率分别为20.51%、94.87%,均优于对照组的51.28%、76.92%,差异均有统计学意义(P<0.05)。结论:急性百草枯中毒治疗过程中,通过参附注射液联合持续血液灌流不仅可以改善患者肺损伤,同时有助于肺纤维化发生率降低,确保良好的治疗效果,值得采纳并推广。Objective:To analyze the effect of Shenfu Injection combined with continuous hemoperfusion on patients with acute paraquat poisoning(APP)and its effect on lung injury.Method:From January 2018 to January 2019,78 patients with acute paraquat poisoning in our hospital were selected,according to the time of admission,they were divided into two groups.The control group(n=39)was treated with the routine drug treatment and continuous blood perfusion,the research group(n=39)was treated with continued blood perfusion combined with Shenfu Injection.The incidence of clinical and pulmonary fibrosis before and after treatment were counted.Result:There were no statistically significant differences in nitric oxide,typeⅢprocollagen peptide and inducible nitric oxide synthase of two groups before treatment(P>0.05).After treatment,the indexes in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).The incidence of pulmonary fibrosis in the study group and the total effective rate of treatment were 20.51%and 94.87%respectively,better than 51.28%and 76.92%of the control group,the differences were statistically significant(P<0.05).Conclusion:In the course of treatment of acute paraquat poisoning,Shenfu Injection combined with continuous hemoperfusion can not only improve the lung injury,but also help to reduce the incidence of pulmonary fibrosis and ensure good therapeutic effect,which is worth adopting and popularizing.

关 键 词：百草枯 中毒 肺损伤 持续血液灌流 参附注射液 影响 

分 类 号：R47[医药卫生—护理学]