妊娠中晚期羊水过少治疗中辅以小剂量低分子肝素的效果  

Effect of Low-dose Low Molecular Weight Heparin Supplemented in the Treatment of Oligohydramnios in the Second Trimester of Pregnancy

作　　者：丁艳娜 DING Yanna(Xiaonan District Maternal and Child Health Hospital of Xiaogan City,Xiaogan 432000,China)

机构地区：[1]孝感市孝南区妇幼保健院

出　　处：《中外医学研究》2019年第34期146-148,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨妊娠中晚期羊水过少治疗中辅以小剂量低分子肝素的效果。方法:选定2017年6月14日-2018年12月20日笔者所在医院收诊的112例妊娠中晚期羊水过少患者,采用区组随机法分为观察组56例(静脉补液传统疗法联合小剂量低分子肝素)与对照组56例(静脉补液传统疗法),比较两组新生儿体重、脐动脉血流阻力(S/D)、最大羊水池深度(AFD)、羊水指数(AFI)、纤维蛋白原含量(FIB)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、Apgar评分≤7分率、剖宫产率、早产率指标。结果:治疗结束,观察组Apgar评分≤7分率(3.57%)、剖宫产率(30.36%)、早产率(8.93%)、S/D(1.67±0.21)均低于对照组,差异均有统计学意义(P<0.05);观察组新生儿体重(3.49±0.46)kg、AFD(48.53±6.67)mm、AFI(146.58±8.06)mm高于对照组,差异均有统计学意义(P<0.05);观察组FIB(2.71±0.39)g/L、TT(17.27±2.51)s、APTT(29.76±3.35)s、PT(12.14±0.49)s,与对照组比较,差异均无统计学意义(P>0.05)。结论:小剂量低分子肝素可有效提高妊娠中晚期羊水过少患者预后质量,改善妊娠结局,值得推广使用。Objective:To investigate the effect of Heparin supplemented in the treatment of oligohydramnios in middle and late pregnancy.Method:A total of 112 patients with oligohydramnios in the second trimester of pregnancy were enrolled from June 14,2017 to December 20,2018.The randomized method was divided into observation group of 56 patients(venous rehydration traditional therapy combined with low-dose Low Molecular Weight Heparin)and the control group of 56 patients(venous rehydration traditional therapy).Compared the body mass,umbilical artery blood flow resistance(S/D),maximum amniotic fluid depth(AFD),amniotic fluid index(AFI),fibrinogen(FIB)content,thrombin time(TT),activated partial thromboplastin time(APTT),prothrombin time(PT),Apgar score≤7 fraction,cesarean section rate,early birth rate.Result:At the end of treatment,the Apgar score≤7(3.57%),cesarean section rate(30.36%),premature rate(8.93%),and S/D(1.67±0.21)were lower in the observation group than those in the control group,the differences were statistically significant significance(P<0.05).The body weight of(3.49±0.46)kg,AFD of(48.53±6.67)mm,AFI of(146.58±8.06)mm in the observation group were higher than those in the control group,and the differences were significant(P<0.05).The FIB of(2.71±0.39)g/L,TT(17.27±2.51)s,APTT of(29.76±3.35)s,PT of(12.14±0.49)s in the observation group were compared with the indexes in the control group,and there were no significantly differences(P>0.05).Conclusion:Low-dose Low Molecular Weight Heparin can effectively improve the prognosis quality of patients with oligohydramnios during pregnancy and improve pregnancy outcome,which is worthy of popularization.

关 键 词：小剂量低分子肝素 羊水 妊娠期 静脉补液 

分 类 号：R71[医药卫生—妇产科学]