布朗卷柏黄酮类化学成分研究  

Study on Flavonoids from Selaginella Braunii Baker

作　　者：曲建博 吴威 肖玲[3] 孙惠惠 朱晖 邹振兴 张燕 陈思为 刘恒宇 周辉[4] 徐康平 QU Jianbo;WU Wei;XIAO Ling;SUN Huihui;ZHU Hui;ZOU Zhenxing;ZHANG Yan;CHEN Siwei;LIU Hengyu;ZHOU Hui;XU Kangping(Center for Drug Evaluation,National Medical Products Administration,Beijing,100022,China;Xiangya School of Pharmaceutical Sciences,Central South University,Changsha,Hunan,410013,China;School of Basic Medical Science,Central South University,Changsha,Hunan,410013,China;Department of Lymphoma Hematology,Hunan Cancer Hospital,Changsha,Hunan,410013,China)

机构地区：[1]国家药品监督管理局药品审评中心,北京100022 [2]中南大学湘雅药学院,湖南长沙410013 [3]中南大学基础医学院,湖南长沙410013 [4]湖南省肿瘤医院淋巴瘤血液内科,湖南长沙410013

出　　处：《肿瘤药学》2019年第6期859-864,共6页Anti-Tumor Pharmacy

基　　金：国家自然科学基金(31370370);湖南省中医药科研计划(201768);湖南省普通高等学校教学改革研究项目/中南大学深化创新创业教育改革研究项目(2019CG006);湖南省研究生科研创新项目(CX20190247);长沙市科技计划(kq1801072);中南大学研究生自主探索创新项目(2019zzts752)

摘　　要：目的研究布朗卷柏(Selaginella braunii Baker)中的黄酮类成分。方法采用正相硅胶柱、Sephadex LH-20柱色谱及半制备高效液相色谱等分离方法对布朗卷柏的75%乙醇提取物进行分离纯化,并根据化合物的理化性质和波谱数据进行结构鉴定。结果从布朗卷柏的75%乙醇提取物中分离得到10个黄酮类化合物,分别鉴定为8’’-methylnaringeninyl-(4’’’,O,3)-kaempferol(1)、2’’,3’’-dihydroochnaflavone(2)、白果黄素(3)、穗花杉双黄酮(4)、kaempferol-3,7-di-O-β-D-glucopyranoside(5)、芹菜素6,8-二-C-β-D-葡萄糖苷(6)、芹菜素6-C-β-D-葡萄糖-8-C-α-L-阿拉伯糖苷(7)、4’-羟基-5-羧甲基黄酮-7-O-β-D-葡萄糖苷(8)、7,4’-二羟基-5-羧甲基黄酮(9)、山奈酚(10)。结论共得到10个化合物,且10个化合物均为首次从布朗卷柏中分离得到。Objective To study the chemical constituents of flavonoids in Selaginella braunii Baker.Methods The constituents were isolated and purified by column chromatographies on silica gel column,Sephadex LH-20 column and Prep-HPLC chromatographic methods,and their structures were elucidated by chemical and spectroscopic methods.Results Ten compounds were identified as 8’’-methylnaringeninyl-(4’’’,O,3)-kaempferol(1),2’’,3’’-dihydroochnaflavone(2),bilobetin(3),amentobiflavonoid(4),kaempferol-3,7-di-O-β-D-glucopyranoside(5),apingenin 6,8-di-C-β-D-glucopyranoside(6),apingenin 6-C-β-D-glucopyranosyl-8-α-L-arabinopyranoside(7),4’-hydroxy-5-carboxymethyl-flavonoid-7-O-β-D-glucopyranoside(8),7,4’-hydroxy-5-carboxymethyl-flavonoid(9),kaempferol(10).Conclusion Compounds 1-10 were all isolated from this plant for the first time.

关 键 词：布朗卷柏 化学成分 黄酮类 

分 类 号：R9[医药卫生—药学]