不同促甲状腺激素水平对不孕症患者行体外受精/卵泡浆内单精子注射-胚胎移植结局的影响  

Effects of different TSH levels on IVF/ICSI-ET outcomes in infertile patients

作　　者：彭超男 张晓敏 杨贵芳 王云燕[2] 杨晓丽[2] 李淑珍 PENG Chaonan;ZHANG Xiaomin;YANG Guifang;WANG Yunyan;YANG Xiaoli;LI Shuzhen(Departmen of Epidemiology,School of Public Health,Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学公共卫生学院流行病学教研室,太原030001 [2]太原市中心医院生殖中心,太原030009

出　　处：《实用医学杂志》2019年第24期3769-3772,3777,共5页The Journal of Practical Medicine

基　　金：国家自然科学基金(编号：81471478)

摘　　要：目的观察不孕症患者中不同TSH水平对体外受精/卵泡浆内单精子注射-胚胎移植(in vitro fertilization/follicle intracytoplasmic sperm injection-embryo transfer,IVF/ICSI-ET)促排卵结局及妊娠结局的影响。方法回顾性分析太原市中心医院生殖中心2018年1月至2019年6月186例不孕患者不同TSH水平下行IVF/ICSI-ET助孕治疗的结局,分为A组(TSH<2.5 mU/L)、B组(2.5 mU/L≤TSH≤4 mU/L)均93例,记录并比较两组患者的一般情况、超促排卵治疗情况及妊娠结局。结果两组患者一般资料、促性腺激素(Gn)(总量/使用时间)、注射人绒毛膜促性腺激素日(E2/LH/P)、取卵日E2、获卵数、卵裂总数差异无统计学意义(P>0.05);正常受精率、晚期卵裂率、优质胚胎率、OHSS发生率及累计种植率、累计临床妊娠率、累计流产率差异均有统计学意义(P<0.05)。结论TSH<2.5 mU/L组患者可获得更高的正常受精率、优质胚胎率、累计种植率、累计临床妊娠率及较低的晚期卵裂率和累计流产率,并且OHSS发生率降低。Objective To observe the effect of TSH levels on ovulation induction and pregnancy outcome of IVF/ICSI-ET IN infertility patients. Methods Retrospective analysis was performed on the outcomes of IVF/ICSIET assisted pregnancy treatment in the reproductive center of Taiyuan central hospital from January 2018 to June2019 in 186 infertile patients with different TSH levels,divided into group A(TSH < 2.5 mu/L)and group B(2.5 mu/L≤TSH≤4 mu/L)with 93 cases,and the general situation of the patients in the two groups,super-ovulation induction treatment and pregnancy outcome were recorded and compared. Results There were no significant differences in general information,gonadotropin(Gn)(total amount/time of use),HCG injection day(E2/LH/P),egg retrieval day(E2/LH/P),number of eggs obtained and total number of cleavage between the two groups(P >0.05). There were statistically significant differences in normal fertilization rate,late cleavage rate,high-quality embryo rate,OHSS incidence rate,cumulative implantation rate,cumulative clinical pregnancy rate,and cumulative abortion rate(P < 0.05). Conclusion TSH < 2.5 mU/L group patients can obtain higher normal fertilization rate,high quality embryo rate,accumulative implantation rate,accumulative clinical pregnancy rate,and lower late cleavage rate and accumulative abortion rate,accompanied with the reduced incidence of OHSS.

关 键 词：体外受精/卵细胞质内单精子注射-胚胎移植 促甲状腺激素 促排卵 妊娠 

分 类 号：R71[医药卫生—妇产科学]