乙型脑炎疫苗研发及应用研究进展  

Progress on Development and Application on Japanese Encephalitis Vaccines

作　　者：高婷 袁芳艳[1] 刘泽文[1] 刘威[1] 周丹娜[1] 杨克礼[1] 段正赢[1] 郭锐[1] 梁婉 焦祖武[1] 田永祥[1] GAO Ting;YUAN Fang-yan;LIU Ze-wen;LIU Wei;ZHOU Dan-na;YANG Ke-li;DUAN Zheng-ying;GUO Rui;LIANG Wan;JIAO Zu-wu;TIAN Yong-xiang(Institute of Animal Husbandry and Veterinary Medicine of Hubei Acadamy of Agricalture Science/Key Laboratory of Prevention and Control Agents for Animal Bacteriosis,Wuhan,Hubei,430064,China)

机构地区：[1]湖北省农业科学院畜牧兽医研究所/农业农村部畜禽细菌病防治制剂创制重点实验室

出　　处：《动物医学进展》2020年第1期83-87,共5页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(31802189,31602082);国家重点研发计划项目(2017YFD0500201);农业农村部畜禽细菌病防治制剂创制重点实验室青年人才基金项目(KLPCAAB-YTP-1802);湖北省农业科学院青年科学基金项目(2018NKYJJ11)

摘　　要：乙型脑炎是由日本脑炎病毒引起的一种人兽共患的蚊媒传染病,它对人类危害巨大,并且给养猪业造成了严重的经济损失,目前临床上还无有效的药物用于治疗该病,而接种乙型脑炎疫苗能有效预防该疫病的流行。自乙型脑炎病毒疫苗应用以来,乙型脑炎的发病率大大下降。论文介绍了乙型脑炎疫苗的发展过程及生产工艺技术,总结了灭活疫苗、减毒活疫苗以及嵌合减毒活疫苗的免疫效果、优势和不足,最后探讨了当前乙型脑炎疫苗可能存在的安全问题以及新型乙型脑炎疫苗的发展方向,以期为新型乙型脑炎疫苗的研发提供参考,为乙型脑炎的防控提供新的思路与科学依据。Japanese encephalitis virus(JEV),a mosquito-borne flavirus,is a major cause of Japanese encephalitis which is a zoonosis.JEV infection can cause severe damage to human being,and also brings serious economic loss to pig husbandry.However,there is no effective treatment,vaccination is the most effective method for preventing the disease.This paper introduced the development process and production technology of JEV vaccine,then summarized the immunization effect,advantages and disadvantages of the inactivated vaccine,attenuated live vaccine,and chimeric attenuated vaccine.Finally we discussed the potential safety problem about current vaccines,the development direction of the new type vaccine in order to provide scientific basis for the prevention and control of Japanese encephalitis.

关 键 词：乙型脑炎 灭活疫苗 减毒活疫苗 嵌合疫苗 

分 类 号：S852.659.6[农业科学—基础兽医学] S852.43[农业科学—兽医学]