阿奇霉素联合脂溶性维生素对支原体肺炎患儿趋化因子 抗氧化物质及心肌酶的影响  

Effects of azithromycin combined with fat-soluble vitamin on chemokines,antioxidants and myocardial enzyme in children with mycoplasma pneumonia

作　　者：肖云斌[1] 林艳[1] 尹惠梅 Xiao Yunbin;Lin Yan;Yin Huimei(Department of Pediatrics,Affiliated Hospital of Hangzhou Normal University,Zhejiang 310000,China)

机构地区：[1]杭州师范大学附属医院儿科,310000

出　　处：《中国药物与临床》2020年第2期179-182,共4页Chinese Remedies & Clinics

摘　　要：目的探讨阿奇霉素联合脂溶性维生素对支原体肺炎患儿趋化因子、抗氧化物质及心肌酶的影响。方法选取2017年1月至2018年6月杭州师范大学附属医院收治的130例支原体肺炎患儿作为研究对象,按随机数表法随机分为观察组65例与对照组65例,对照组患儿接受阿奇霉素单药治疗,观察组在对照组的基础上联合注射用脂溶性维生素I,检测并比较2组的单核细胞趋化蛋白-4(MCP-4)、巨噬细胞衍生趋化因子(MDC)、半胱氨酰白三烯(CysLTs)、过氧化氢酶(CAT)、髓过氧化物酶(MPO)、超氧化物歧化酶(SOD)、谷胱甘肽-过氧化物酶(GSH-PX)、乳酸脱氢酶(LDH)、肌酸激酶(CK)和肌酸激酶同工酶(CK-MB)。结果治疗前,2组患儿的MCP-4、MDC、CysLTs水平差异均无统计学意义(P>0.05);治疗后,观察组的MCP-4、MDC、CysLTs分别为(54±6)pg/ml、(539±59)pg/ml、(408±50)pg/ml,对照组的MCP-4、MDC、CysLTs分别为(80±9)pg/ml、(891±95)pg/ml、(873±96)pg/ml,2组的MCP-4、MDC、CysLTs均比治疗前降低,且观察组的各指标均低于对照组(均P<0.05)。治疗前,2组患儿的CAT、MPO、SOD、GSH-PX水平差异均无统计学意义(P>0.05);治疗后,观察组的CAT、MPO、SOD、GSH-PX分别为(21.4±1.8)U/L、(70±8)U/L、(139±16)U/L、(121±15)U/L,对照组的CAT、MPO、SOD、GSH-PX分别为(14.6±1.8)U/L、(66±4)U/L、(123±9)U/L、(109±8)U/L,2组的CAT、MPO、SOD、GSH-PX均比治疗前升高,且观察组的各指标水平高于对照组(均P<0.05)。治疗前,2组患儿的LDH、CK、CK-MB水平差异均无统计学意义(P>0.05);治疗后,观察组的LDH、CK、CK-MB水平分别为(132±23)U/L、(103±19)U/L、(16±4)U/L,对照组的LDH、CK、CK-MB水平分别为(164±19)U/L、(119±20)U/L、(24±8)U/L,2组的LDH、CK、CK-MB水平均比治疗前降低,且观察组的各指标水平低于对照组(均P<0.05)。结论阿奇霉素联合脂溶性维生素能够显著改善支原体肺炎患儿的趋化因子、抗氧化物质及心肌酶。Objective To investigate the effects of azithromycin combined with fat-soluble vitamin on chemokines,antioxidants and myocardial enzyme in children with mycoplasma pneumonia.Methods A total of 130 children with mycoplasma pneumonia admitted to the Affiliated Hospital of Hangzhou Normal University were included as the subjects in the study between January 2017 and June 2018.They were randomly divided into the study group and control group(n=65 each).The control group received monotherapy with azithromycin.In addition,the study group received injection of lipid-soluble vitamin I.The levels of monocyte chemoattractant protein-4(MCP-4),macrophage-derived chemokine(MDC),cysteinyl leukotrienes(CysLTs),catalase(CAT),myeloperoxidase(MPO),superoxide dismutase(SOD),glutathione-peroxidase(GSH-PX),lactate dehydrogenase(LDH),creatine kinase(CK)and creatine kinase isoenzyme(CK-MB)in the two groups were determined and compared.Results There were no statistically significant differences in MCP-4,MDC and CysLTs levels at the baseline between the two groups(all P>0.05).After the treatment,the levels of MCP-4,MDC,and CysLTs were(54±6)pg/ml,(539±59)pg/mk,(408±50)pg/ml in the study group,and(80±9)pg/ml,(891±95)pg/ml,(873±96)pg/ml in the control group,respectively.The levels of MCP-4,MDC and CysLTs after the treatment in the two groups were lower than those at the baseline,and the levels in the study group were lower than those in the control group(all P<0.05).There were no statistically significant differences in CAT,MPO,SOD and GSH-PX levels between the two groups at the baseline(all P>0.05).After the treatment,the levels of CAT,MPO,SOD,and GSH-PX were(21.4±1.8)U/L,(70±8)U/L,(139±16)U/L,(121±15)U/L in the study group,and(14.6±1.8)U/L,(66±4)U/L,(123±9)U/L,(109±8)U/L in the control group,respectively.The levels of CAT,MPO,SOD and GSH-PX after the treatment in the two groups were higher than those at the baseline,and the levels in the study group were higher than those in the control group(all P<0.05).There were no statis

关 键 词：阿奇霉素 维生素类 肺炎 支原体 趋化因子类 心肌酶 

分 类 号：R725.6[医药卫生—儿科]