米非司酮联合甲氨蝶呤治疗异位妊娠的临床效果  

Clinical effect of Mifepristone combined with Methotrexate in the treatment of ectopic pregnancy

作　　者：梁伟颜 LIANG Wei-yan(Department of Obstetrics and Gynecology,People's Hospital of Yangdong District in Yangjiang City,Guangdong Province,Yangjiang 529500,China)

机构地区：[1]广东省阳江市阳东区人民医院妇产科

出　　处：《中国当代医药》2020年第1期147-149,共3页China Modern Medicine

摘　　要：目的探讨米非司酮联合甲氨蝶呤治疗异位妊娠的临床效果。方法选取2016年2月~2018年7月我院收治的40例异位妊娠患者作为研究对象,根据患者入院后病床尾号单双号的不同将其分为对照组(20例)和观察组(20例)。对照组患者采用单纯甲氨蝶呤治疗,观察组患者在对照组用药基础上加用米非司酮治疗。比较两组患者临床治疗效果、不良反应发生情况、血清β-人绒毛膜促性腺激素(β-HCG)水平及其下降至正常范围所需时间。结果观察组患者的治疗有效率为90.00%,高于对照组的40.00%,差异有统计学意义(P<0.05)。观察组患者的不良反应总发生率为5.00%,低于对照组的30.00%,差异有统计学意义(P<0.05)。治疗前,两组患者的血清β-HCG水平比较,差异无统计学意义(P>0.05);观察组患者治疗后的血清β-HCG水平低于对照组,差异有统计学意义(P<0.05)。观察组患者血清β-HCG下降至正常范围所需时间短于对照组,差异有统计学意义(P<0.05)。结论与单纯甲氨蝶呤治疗比较,米非司酮联合甲氨蝶呤治疗异位妊娠的效果较好,不良反应发生率较低,能够更快地降低患者血清β-HCG水平,缩短治疗时间,值得临床应用与推广。Objective To investigate the clinical effect of Mifepristone combined with Methotrexate in the treatment of ectopic pregnancy.Methods Forty patients with ectopic pregnancy admitted to our hospital from February 2016 to July 2018 were selected as the research objects,and were divided into control group(20 cases)and observation group(20 cases)according to the difference of single and double hospital bed tail numbers after admission.The patients in the control group were treated with Methotrexate alone,while the patients in the observation group were treated with Mifepristone on the basis of the drugs used in the control group.The clinical therapeutic effect,adverse reactions,serum β-human chorionic gonadotropin(β-HCG)level and the time required to fall to the normal range were compared between the two groups.Results The effective rate of treatment in the observation group was 90.00%,higher than that in the control group(40.00%),and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the observation group was 5.00%,lower than that in the control group(30.00%),and the difference was statistically significant(P<0.05).The serum β-HCG levels before treatment were compared between the two groups,and the difference was not statistically significant(P>0.05).The level of serum β-HCG in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The time required to reduce β-HCG to the normal range in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Compared with Methotrexate alone,Mifepristone combined with Methotrexate has a better effect on ectopic pregnancy with lower incidence of adverse reactions.It can reduce the serum β-HCG level of patients faster and shorten the treatment time,which is worthy of clinical application and promotion.

关 键 词：米非司酮 甲氨蝶呤 异位妊娠 血清β人绒毛膜促性腺激素 

分 类 号：R979[医药卫生—药品]