中老年患者血清tPSA轻度异常时PSA相关指标鉴别无症状性前列腺炎与前列腺癌的价值  

The Value of PSA Related Indicators in the Differential Diagnosis of Serum tPSA in Elderly Patients with Asymptoma tic Prostatitis and Prostate Cancer

作　　者：王启明[1] 倪颖[1] 周金才[1] 姜大业[1] WANG Qi-ming;NI Ying;ZHOU Jin-cai;JIANG Da-ye(Department of Urology,Jianhu County People's Hospital,Nantong University,Yancheng,Jiangsu Province,224700 China)

机构地区：[1]南通大学附属建湖县人民医院泌尿外科

出　　处：《系统医学》2019年第23期80-82,共3页Systems Medicine

摘　　要：目的探究中老年患者血清总前列腺特异性抗原(tPSA)轻度异常时,无症状性前列腺炎、前列腺癌应用前列腺特异性抗原(PSA)相关指标鉴别的价值。方法选取该院2017年1月—2018年12月收治的72例中老年(血清tPSA轻度异常4~20μg/L)男性患者为研究对象,其中无症状性前列腺炎组(56例,经过病理活检确诊为无症状前列腺炎)、前列腺癌组(16例,经过病理活检确诊为前列腺癌),比较两组患者tPSA、PSA密度(PSAD)、移行区PSA密度(TZPSAD)指标,以及前列腺相关测量数据情况。结果无症状性前列腺炎组(11.31±2.14)μg/L、前列腺癌组患者(12.48±2.08)μg/L,tPSA组间数据比较,差异无统计学意义(t=1.940,P=0.056>0.05),前列腺癌组患者PSAD(0.20±0.04)μg/(L·cm^3)、TZPSAD(0.31±0.06)μg/(L·cm^3)指标均比无症状性前列腺炎组水平高,差异有统计学意义(t=9.097、18.557;P=0.000、0.000<0.05);通过前列腺相关数据测量结果得出,相比前列腺癌组,无症状性前列腺炎组患者的前列腺总体积(96.05±22.34)cm^3、移行区体积(60.12±5.67)cm^3明显要更大,差异有统计学意义(t=5.558、22.044,P=0.001、0.001<0.05),但两组的外周带体积情况比较,差异无统计学意义(t=0.095,P=0.925>0.05)。结论中老年患者血清tPSA轻度异常时,PSA相关指标、前列腺相关数据测量用于无症状性前列腺炎、前列腺癌诊断价值高,值得推广。Objective To investigate the value of prostate specific antigen(PSA)related markers in asymptomatic prostatitis and prostate cancer in patients with mild abnormalities of serum total prostate specific antigen(tPSA)in middle-aged and elderly patients.Methods A total of 72 male patients(small tPSA mild abnormalities 4~20μg/L)were enrolled in the hospital from January 2017 to December 2018.Among them,in the asymptomatic prostatitis group(56 patients underwent pathology biopsy),prostate cancer group(16 cases,confirmed by pathological biopsy as prostate cancer),comparing tPSA,PSA density(PSAD),transition zone PSA density(TZPSAD),and prostate-related measurements in both groups data situation.Results There were no differences in the data between the asymptomatic prostatitis group(11.31±2.14)μg/L and the prostate cancer group(12.48±2.08)μg/L,tPSA group,the difference was not statistically significant(t=1.940,P=0.056>0.05),and the prostate cancer group patients with PSAD(0.20±0.04)μg/(L·cm^3)and TZPSAD(0.31±0.06)μg/(L·cm^3)were higher than those in the asymptomatic prostatitis group,and there were statistical differences(t=9.097,18.557;P=0.000,0.000<0.05).Compared with the prostate cancer group,the total prostate volume(96.05±22.34)cm^3 and the transition zone volume(60.12±5.67)cm^3 were significantly larger and different in the asymptomatic prostatitis group,which was statistically significant(t=5.558,22.044,P=0.001,0.001<0.05),but the peripheral volume of the two groups was not statistically significant(t=0.995,P=0.925>0.05).Conclusion In the mild abnormalities of serum tPSA in middle-aged and elderly patients,PSA-related indicators and prostate-related data are valuable for the diagnosis of asymptomatic prostatitis and prostate cancer,which is worthy of promotion.

关 键 词：前列腺炎 前列腺癌 前列腺特异性抗原 

分 类 号：R697.3[医药卫生—泌尿科学] R737.25[医药卫生—外科学]