血清血管生成素1与血管生成素2比值对2型糖尿病微血管病变的诊断价值  

Diagnostic value of serum angiopoietin 1 and angiopoietin 2 ratio in microangiopathy of type 2 diabetes

作　　者：句卫玲[1] 李兴[2] 郑淑君[3] 张娟 甄璐 JU Weiling;LI Xing;ZHENG Shujun;ZHANG Juan;ZHEN Lu(Shanxi Medical University,Taiyuan,Shanxi 030001,China;Department of Endocrinology,the Second Affiliated Hospital of Shanxi Medical University,Taiyuan,Shanxi 030001,China;Department of Endocrinology,General Hospital of Taiyuan Iron and steel(Group)Co.,Ltd,Taiyuan,Shanxi 030001,China)

机构地区：[1]山西医科大学,山西太原030001 [2]山西医科大学附属第二医院内分泌科,山西太原030001 [3]太原钢铁(集团)有限公司总医院内分泌科,山西太原030001

出　　处：《国际检验医学杂志》2020年第1期29-32,36,共5页International Journal of Laboratory Medicine

基　　金：山西省国际科技合作项目计划（2015081031）;山西省应用基础研究项目计划（201801D121214）

摘　　要：目的 探讨血清血管生成素1(Ang-1)与血管生成素2(Ang-2)比值对2型糖尿病(T2DM)微血管病变的诊断价值。方法 选取2018年1-12月期间在山西医科大学附属第二医院(下称本院)接受治疗的T2DM患者98例,根据是否合并微血管病变将98例患者分为微血管病变组(42例)和单纯T2DM组(56例),另选取同期在本院体检的健康人群50例作为对照组。检测各组研究对象的空腹血糖(FPG)、糖化血红蛋白(HbA1c)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)、Ang-1、Ang-2、Ang-1/Ang-2。结果 微血管病变组的体质量指数、FPG、HbA1c、HOMA-IR、Ang-2均高于单纯T2DM组和对照组,Ang-1/Ang-2低于单纯T2DM组和对照组,差异有统计学意义(P<0.05),微血管病变组的病程长于单纯T2DM组,FINS高于对照组,差异有统计学意义(P<0.05),单纯T2DM组的体质量指数、FPG、FINS、HbA1c、HOMA-IR、Ang-2均高于对照组,Ang-1/Ang-2低于对照组,差异有统计学意义(P<0.05),Ang-2与病程、HbA1c呈正相关(r分别为0.421、0.391,P<0.05),Ang-1/Ang-2与病程、HbA1c呈负相关(r分别为-0.548、-0.423,P<0.05),Ang-1、Ang-2、Ang-1/Ang-2曲线下的面积分别为0.625、0.737、0.902,约登指数分别为0.134、0.549、0.744。结论 血清Ang-2在T2DM微血管病变患者中呈高表达,而Ang-1/Ang-2则明显降低,且Ang-1/Ang-2对T2DM患者微血管病变有较高的诊断价值。Objective To investigate the diagnostic value of serum angiopoietin 1(Ang-1)and angiopoietin 2(Ang-2)ratio for type 2 diabetes mellitus(T2DM)microangiopathy.Methods 98 patients with T2DM who were treated in the Second Affiliated Hospital of Shanxi Medical University from January 2018 to December 2018 were enrolled in the study.According to whether or not microvascular disease was included,98 patients were divided into microvascular disease group(42 cases)and T2DM group(56 cases).50 healthy people in the same period in the hospital were selected as the control group.Fasting blood glucose(FPG),glycosylated hemoglobin(HbA1c),fasting insulin(FINS),insulin resistance index(HOMA-IR),Ang-1,Ang-2,Ang-1/Ang-2 were measured in each group.Results The body mass index,FPG,HbA1c,HOMA-IR and Ang-2 in the microangiopathy group were higher than those in the T2DM group and the control group.The Ang-1/Ang-2 was lower than the T2DM group and the control group,and the differences were statistically significant(P<0.05).The course of the microangiopathy group was longer than that of the T2DM group,and the FINS was higher than that in the control group and the differences were statistically significant(P<0.05).The body mass index,FPG,FINS,HbA1c,HOMA-IR and Ang-2 in the T2DM group were higher than those in the control group,and Ang-1/Ang-2 was lower than the control group and the differences were statistically significant(P<0.05).Ang-2 was positively correlated with disease course and HbA1c(r=0.421,0.391,P<0.05),while Ang-1/Ang-2 was negatively correlated with disease course and HbA1c(r=-0.548,-0.423,P<0.05).The areas under Ang-1,Ang-2 and Ang-1/Ang-2 curves were 0.625,0.737 and 0.902,respectively,and the Yoden indexes were 0.134,0.549 and 0.744,respectively.Conclusion Serum Ang-2 is highly expressed in patients with T2DM microangiopathy,while Ang-1/Ang-2 is significantly decreased,and Ang-1/Ang-2 has a high diagnostic value for microangiopathy in T2DM patients.

关 键 词：血管生成素1 血管生成素2 2型糖尿病 微血管病变 诊断价值 

分 类 号：R587.2[医药卫生—内分泌] R543[医药卫生—内科学]