新生儿缺氧性肺动脉高压血清内皮素-1、血管性假血友病因子及Tei指数与肺动脉收缩压的关系  

Relationship between serum endothelin-1, von willebrand factor and Tei index and pulmonary artery systolic pressure in neonates with hypoxic pulmonary hypertension

作　　者：杨海娟[1] 许泽辉[1] YANG Haijuan;XU Zehui(Department of 1 st Pediatric,the People′s Hospital of Langfang City of Hebei Province,Hebei Province,Langfang 065000,China)

机构地区：[1]河北省廊坊市人民医院儿一科

出　　处：《中国医药导报》2019年第36期104-107,共4页China Medical Herald

基　　金：河北省科技计划项目（172777223）

摘　　要：目的探讨新生儿缺氧性肺动脉高压(HPH)血清内皮素-1(ET-1)、血管性假血友病因子(vWF)及心肌做功(Tei)指数与肺动脉收缩压(PASP)的关系。方法选取2016年1月~2019年1月河北省廊坊市人民医院(以下简称“我院”)收治的HPH新生儿113例,按照PASP水平高低不同分为轻度组(n=37)、中度组(n=38)和重度组(n=38),另选取同期在我院出生的健康新生儿39例作为对照组。比较各组血清ET-1、vWF水平、动脉血气分析指标及Tei指数、PASP,Pearson积距相关分析血清ET-1、vWF水平与Tei指数、PASP的相关性。结果4组血清vWF、ET-1水平及Tei指数、PASP比较,差异均有高度统计学意义(均P<0.01)。轻度组、中度组、重度组血清vWF、ET-1水平、Tei指数、PASP均高于对照组,差异均有统计学意义(均P<0.05)。4组动脉血气分析指标比较,差异均有高度统计学意义(均P<0.01)。轻度组、中度组、重度组SaO 2、PaO 2均低于对照组,PaCO 2高于对照组,差异均有统计学意义(均P<0.05)。Pearson积距相关分析显示,血清ET-1、vWF水平及Tei指数与PASP呈正相关(r=0.839、0.866、0.657,P<0.05);血清ET-1、vWF水平与Tei指数呈正相关(r=0.530、0.618,P<0.05)。结论血清ET-1、vWF水平及Tei指数变化与HPH新生儿密切相关,临床上可通过检测血清ET-1、vWF水平帮助评估患儿心功能变化及病情进展。Objective To investigate the relationship between serum endothelin-1(ET-1),von willebrand factor(vWF),Tei index and pulmonary artery systolic pressure(PASP)in neonates with hypoxic pulmonary hypertension(HPH).Methods From January 2016 to January 2019,113 cases with HPH neonates who were admitted to the People′s Hospi-tal of Langfang City of Hebei Province(“our hospital”for short)were selected.They were divided into mild group(n=37),moderate group(n=38)and severe group(n=38),according to the level of PASP.In the same period,39 cases with healthy neonates in our hospital were selected as control group.The levels of serum ET-1 and vWF,arterial blood gas analysis index,Tei index and PASP in each group were compared.Pearson correlation analysis was used to analyze the correlation between serum ET-1,vWF levels,Tei index and PASP.Results The serum vWF,ET-1 levels,Tei in-dex and PASP in four groups showed statistically significant differences(all P<0.01).The serum vWF,ET-1 levels,Tei index and PASP in mild group,moderate group and severe group were higher than those in control group,and the differences were statistically significant(all P<0.05).Arterial blood gas analysis index in four groups showed statisti-cally significant differences(all P<0.01).SaO 2,PaO 2 in mild group,moderate group and severe group were lower than those in control group,PaCO 2 in mild group,moderate group and severe group were higher than that in control group,and the differences were statistically significant(all P<0.05).Pearson correlation analysis showed that serum ET-1 and vWF levels and Tei index of HPH neonates were positively correlated with PASP(r=0.839,0.866,0.657,P<0.05).The serum ET-1 and vWF levels were positively correlated with Tei index(r=0.530,0.618,P<0.05).Conclusion The changes of ET-1,vWF levels and Tei index are closely related to HPH newborns.Clinically,serum ET-1 and vWF levels can be detected to help e-valuate the changes in cardiac function and disease progression of children.

关 键 词：缺氧性肺动脉高压 新生儿 内皮素-1 肺动脉收缩压 心肌做功指数 

分 类 号：R722.1[医药卫生—儿科]