乌灵胶囊联合氟西汀胶囊治疗心肾不交型2型糖尿病伴情绪障碍的临床效果  

Clinical effect of Wuling Capsules combined with Fluoxetine Capsules in the treatment of type 2 diabetes mellitus with heart-kidney disharmony and emotional handicap

作　　者：刘焱[1] 李月[2] 刘怡 王会颖[2] LIU Yan;LI Yue;LIU Yi;WANG Huiying(Department of Traditional Chinese Medicine,Aerospace Center Hospital,Beijing 100039,China;Community Center,Aerospace Center Hospital,Beijing 100039,China)

机构地区：[1]航天中心医院中医科,北京100039 [2]航天中心医院社区中心,北京100039

出　　处：《中国医药导报》2019年第34期122-125,共4页China Medical Herald

基　　金：首都卫生发展科研专项项目(首发2018-3P-7042)

摘　　要：目的研究乌灵胶囊联合氟西汀胶囊治疗心肾不交型2型糖尿病伴情绪障碍的临床效果。方法选择2017年5月~2018年12月于航天中心医院接受治疗的103例心肾不交型2型糖尿病伴情绪障碍患者进行研究。按照随机数字表法将患者分为对照组(51例)和治疗组(52例),两组患者均接受常规的控制血糖治疗。对照组患者口服盐酸氟西汀胶囊,治疗组患者在对照组基础上服用乌灵胶囊,两组患者均接受12周连续治疗。比较两组临床疗效、汉密尔顿抑郁量表(HDRS-17)评分、中医证候评分、血糖水平、胰岛素抵抗指数(HOMA-IR)及不良反应。结果治疗组的临床总有效率明显高于对照组,差异有统计学意义(P<0.05)。两组治疗后的HDRS-17评分及中医证候评分均低于治疗前,且治疗组低于对照组(P<0.05)。两组治疗后的空腹血糖、糖化血清白蛋白及HOMA-IR均低于治疗前,且治疗组低于对照组(P<0.05)。两组的不良反应发生率比较,差异无统计学意义(P>0.05)。结论乌灵胶囊联合氟西汀胶囊治疗心肾不交型2型糖尿病伴随情绪障碍的效果明显,安全性也较高,还可有效减轻患者的抑郁程度,改善血糖水平及胰岛素抵抗,值得临床关注。Objective To explore clinical effect of Wuling Capsules combined with Fluoxetine Capsules in the treatment of type 2 diabetes mellitus with heart-kidney disharmony and emotional handicap.Methods One hundred and three type 2 diabetes mellitus patients with heart-kidney disharmony and emotional handicap in Aerospace Center Hospital from May 2017 to December 2018 were selected for the study.The patients were divided into control group(n=51)and treatment group(n=52)according to random number table method.Both groups received routine glycemic control therapy.Fluoxetine Hydrochloride Capsules were taken orally in control group.Wuling Capsules were taken orally in treatment group on the basis of control group.Patients in both groups received continuous treatment for 12 weeks.Clinical efficacy,Hamilton depression rating scale(HDRS-17)score,traditional Chinese medicine syndrome score,blood glucose level,HOMA-IR and adverse reactions were compared between two groups.Results Total clinical effective rate of treatment group was significantly higher than that of control group(P<0.05).After treatment,HDRS-17 score and traditional Chinese medicine syndrome score of two groups were lower than those before treatment,and those in treatment group were lower than those in control group(P<0.05).After treatment,fasting blood-glucose,glycated albumin and HOMA-IR in two groups were lower than those before treatment,and those in treatment group were lower than those in control group(P<0.05).There was no significant difference in incidence of adverse reactions between two groups(P>0.05).Conclusion Wuling Capsules combined with Fluoxetine Capsules has obvious effect and high safety in the treatment of type 2 diabetes mellitus with heart-kidney disharmony and emotional handicap.It can also effectively reduce the degree of depression of patients,improve the level of blood glucose and insulin resistance,which is worthy of clinical attention.

关 键 词：乌灵胶囊 氟西汀胶囊 心肾不交 2型糖尿病 情绪障碍 

分 类 号：R587.1[医药卫生—内分泌]