静脉注射利多卡因在无痛胃镜检查中的临床应用  

Clinical application of intravenous infusion of Lidocaine in painless gastroscopy

作　　者：汤莉莉[1] 顾尔伟[1] TANG Lili;GU Erwei(Department of Anesthesiology,the First Affiliated Hospital of Anhui Medical University,Anhui Province,Hefei230032,China)

机构地区：[1]安徽医科大学第一附属医院麻醉科

出　　处：《中国医药导报》2019年第35期139-142,共4页China Medical Herald

基　　金：安徽省科技攻关计划项目(1301042204)

摘　　要：目的 评估静脉注射利多卡因对无痛胃镜检查中丙泊酚用量、心肺不良事件发生情况及术后恢复情况的影响。方法 选择2018年11月~2019年2月安徽医科大学第一附属医院门诊择期行无痛胃镜检查患者180例,采用随机数字表法分为利多卡因组和对照组,每组各90例。利多卡因组麻醉诱导前2 min静脉注射2%利多卡因1.5 mg/kg,对照组给予等容量生理盐水。记录两组丙泊酚诱导剂量、追加剂量和总量,心肺不良事件发生情况和局麻药中毒反应情况以及术后恢复情况。结果 利多卡因组丙泊酚诱导剂量和总量均低于对照组,低血压的发生率低于对照组,术后苏醒时间、应答时间、自如活动时间明显短于对照组,差异有统计学意义(P <0.05)。两组患者术中体动、呼吸抑制、复苏区驻留时间比较,差异无统计学意义(P> 0.05)。无患者出现局麻药中毒反应。结论静脉注射利多卡因运用于无痛胃镜检查中,可降低丙泊酚用量、稳定血流动力学、加速术后恢复。Objective To evaluate the effects of intravenous infusion of Lidocaine on Propofol requirements,incidence of cardiopulmonary adverse events,recovery of post-gastroscopy.Methods From November 2018 to February 2019,a total of 180 consecutive patients undergoing painless gastroscopy in the First Affiliated Hospital of Anhui Medical University were enrolled in the study,while they were divided into Lidocaine group and control group according to the random number table method,with 90 cases in each group.Patients in Lidocaine group were slowly injected with 2%Lidocaine at 1.5 mg/kg,while the equal volume of 0.9%normal saline was given in control group 2 min before induction.Propofol induction,supplementation and total dose,cardiopulmonary adverse events and local anesthetic intoxication,recovery of post-gastroscopy were recorded.Results The requirements of Propofol induction and total dose of Lidocaine group were significantly lower than those of control group,and the incidence of hypotension was lower than that of control group,while the times of postoperative wake-up,response,and free movement of Lidocaine group were significantly shorter than those in control group,and the differences were statistically significant(P<0.05).There were no significant differences in body movement,respiratory depression,and residence time in the resuscitation area between the two groups(P>0.05).Local anesthetic intoxication was not observed.Conclusion Intravenous injection of Lidocaine in painless gastroscopy can reduce Propofol requirements,obtains stability hemodynamics during gastroscopy and accelerates post-gastroscopy recovery.

关 键 词：静脉注射利多卡因 丙泊酚 不良事件 胃镜 

分 类 号：R614[医药卫生—麻醉学]