柴葛芩连汤联合常规治疗对湿热闭肺型小儿支气管肺炎患者的临床疗效  

Clinical effects of Chaige Qinlian Decoction combined with routine treatment on patients with children’s bronchopneumonia due to Damp-heat Blocking Lung Pattern

作　　者：王书玲[1] 侯江红[1] 陈团营[1] 申冬冬[1] WANG Shu-ling;HOU Jiang-hong;CHEN Tuan-ying;SHEN Dong-dong(Henan Provincial Hospital of Traditional Chinese Medicine,Zhengzhou 450002,China)

机构地区：[1]河南省中医院

出　　处：《中成药》2020年第1期85-88,共4页Chinese Traditional Patent Medicine

基　　金：国家中医药管理局十二五中医药重点学科项目(国中医药人教发[2012]32);河南省科技发展计划项目(142300410070);河南省中医药科学研究专项课题(2013ZY02025)

摘　　要：目的考察柴葛芩连汤联合常规治疗对湿热闭肺型小儿支气管肺炎患者的临床疗效。方法 137例患者随机分为对照组(68例)和观察组(69例),对照组给予常规治疗(吸氧、布洛芬、头孢美唑钠、喜炎平注射液),观察组在对照组基础上加用柴葛芩连汤,疗程10 d。检测临床疗效、恢复情况、血清炎症因子(CRP、IL-6、IL-8、TNF-α)、中医证候评分变化。结果观察组总有效率高于对照组(P<0.05),恢复情况(除X线全胸片消失时间外)更明显(P<0.05)。治疗后,2组炎症因子水平、中医证候评分降低(P<0.05),以观察组更明显(P<0.05)。结论柴葛芩连汤可缓解湿热闭肺型小儿支气管肺炎患者症状,其机制可能与下调血清CRP、IL-6、IL-8、TNF-α水平有关。AIM To investigate the clinical effects of Chaige Qinlian Decoction combined with routine treatment on patients with children’s bronchopneumonia due to Damp-heat Blocking Lung Pattern.METHODS One hundred and thirty-seven patients were randomly assigned into control group(68 cases) for 10-day intervention of routine treatment(oxygen inhalation, buprofen, cefmetazole sodium, Xiyanping Injection), and observation group(69 cases) for 10-day intervention of both Chaige Qinlian Decoction and routine treatment. The changes in clinical efficacy, recovery conditions, serum inflammatory factors(CRP, IL-6, IL-8, TNF-α) and TCM syndrome score were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P<0.05), along with better recovery conditions(except for disappearance time of X-ray chest film)(P<0.05). After the treatment, the two groups displayed decreased inflammatory factor levels and TCM syndrome score(P<0.05), especially for the observation group(P<0.05).CONCLUSION For the patients with children’s bronchopneumonia due to Damp-heat Blocking Lung Pattern, Chaige Qinlian Decoction combined with routine treatment can alleviate clinical symptoms, whose mechanisms may contribute to the down-regulation of serum CRP, IL-6, IL-8 and TNF-α levels.

关 键 词：柴葛芩连汤 常规治疗 小儿支气管肺炎 湿热闭肺 

分 类 号：R287[医药卫生—中药学]