石榴花化学成分的研究  

Chemical constituents from the flowers of Punica granatum

作　　者：周彩虹[1] 金晨 赵艳红[1] 熊瑶 李彤 张凌[1] ZHOU Cai-hong;JIN Chen;ZHAO Yan-hong;XIONG Yao;LI Tong;ZHANG Ling(School of Pharmacy,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;Key Laboratory for Modern Preparation of TCM,Ministry of Education,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China)

机构地区：[1]江西中医药大学药学院,江西南昌330004 [2]江西中医药大学现代中药制剂教育部重点实验室,江西南昌330004

出　　处：《中成药》2020年第1期102-106,共5页Chinese Traditional Patent Medicine

基　　金：江西省2011协同创新中心项目(JXXT201402019);江西省教育厅课题(170699)

摘　　要：目的研究石榴Punica granatum L.花的化学成分。方法石榴花60%乙醇提取物采用硅胶、Sephadex LH-20、ODS、半制备液相、重结晶等进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到12个化合物,分别鉴定为β-1,4,6-三-O-没食子酰基葡萄糖(1)、butylbrevifolin carboxylate(2)、短叶苏木酚酸甲酯(3)、短叶苏木酚(4)、β-1,6-二-O-没食子酰基葡萄糖(5)、鞣花酸(6)、鹰嘴豆芽素A(7)、retusin-8-methylether(8)、蒲公英赛醇(9)、谷甾醇(10)、β-谷甾醇棕榈酸酯(11)、 crispin A(12)。结论化合物1~3、7~12为首次从石榴属植物中分离得到,化合物1~4、7~12为首次从该植物中分离得到。AIM To study the chemical constituents from the flowers of Punica granatum L..METHODS The 60% ethanol extract from P. granatum was isolated and purified by silica, Sephadex LH-20, ODS, semi-preparative HPLC and recrystallization,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Twelve compounds were isolated and identified as β-1,4,6-tri-O-galloyl-D-glucose(1), butylbrevifolin carboxylate(2), methy brevifolincarboxylate(3), brevifolin(4), 1,6-di-O-galloyl-β-D-glucopyranose(5), ellagic acid(6), biochanin A(7), retusin-8-methylether(8), taraxerol(9), sitosterol(10), β-sitosterol palmitate(11), crispin A(12).CONCLUSION Compounds 1-3,7-12 are isolated from genus Punica for the first time,and compounds 1-4, 7-12 are isolated from this plant for the first time.

关 键 词：石榴 花 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]