Turner综合征垂体MRI特征及与激素、染色体的关系  

Correlation analysis of pituitary gland MRI with hormone and chromosome in Turner syndrome

作　　者：李蕾[1] 陈志红[2] 李志勇[1] 杨洪秀 牟素萍 Lei Li;Zhi-hong Chen;Zhi-yong Li;Hong-xiu Yang;Su-ping Mu(Department of Pediatrics,People’s Hospital,Weifang,Shandong 261000,China;Department of Neuroendocrinology,The Affiliated Hospital of Qingdao University,Qingdao,Shandong 266003,China;Department of Endocrinology,Women and Children’s Hospital,Qingdao,Shandong 266011,China)

机构地区：[1]潍坊市人民医院小儿内科,山东潍坊261000 [2]青岛大学附属医院神经内分泌儿科,山东青岛266003 [3]青岛市妇女儿童医院内分泌代谢科,山东青岛266011

出　　处：《中国现代医学杂志》2020年第2期95-98,共4页China Journal of Modern Medicine

摘　　要：目的分析Turner综合征患儿的垂体磁共振成像(MRI)表现特征及与相关激素、染色体的关系,探讨垂体改变的原因。方法选取2010年6月-2018年6月于青岛大学附属医院神经内分泌儿科诊治的43例Turner综合征患儿,回顾性分析垂体MRI大小与相关激素、染色体的相关性。结果患儿垂体MRI多见垂体正常(22例,51.2%)和垂体增大(18例,41.9%);垂体正常组促卵泡激素、黄体生成素低于垂体增大组(P <0.05),雌二醇高于垂体增大组(P <0.05)。结论部分Turner综合征患儿垂体形态异常,主要表现为垂体增大,可能与靶腺(卵巢)功能低下引起负反馈抑制作用减弱,导致垂体代偿性增生有关。Objective To analyze the MRI features of pituitary in children with Turner’s syndrome and the relationship with related hormones and chromosomes, and to explore the causes of pituitary changes. Methods Totally 43 children aged 7 to 18 years with Turner syndrome were selected from the Affiliated Hospital of Qingdao university from June 2010 to June 2018. Retrospective analysis of the correlation between MRI size of pituitary gland and both related hormones and chromosomes was performed. Results Most of the patients with pituitary MRI showed normal pituitary(22 cases, 51.2%) and enlarged pituitary(18 cases, 41.9%);the levels of follicle stimulating hormone and luteinizing hormone in the normal pituitary group were lower than those in the enlarged pituitary group(P < 0.05), and estradiol was higher than those in the enlarged pituitary group(P < 0.05). Conclusion Some children with Turner’s syndrome have abnormal pituitary morphology, mainly manifested as pituitary enlargement, which may be related to the compensatory hyperplasia of pituitary due to the decrease of negative feedback inhibition caused by the low function of target gland(ovary).

关 键 词：Turner综合征/综合征 磁共振成像 垂体 

分 类 号：R596.1[医药卫生—内科学]