自拟清肺宽胸理气汤对慢性阻塞性肺疾病急性加重期患者的疗效分析  

Analysis of effect of self-made Qingfeikuanxiongliqi decoction in patients with acute exacerbation of chronic obstructive pulmonary disease

作　　者：苟萍[1] 李仁东 张丽娟 Ping Gou;Ren-dong Li;Li-juan Zhang(Department of Integrated Traditional Chinese and Western Medicine,The Fifth People’s Hospital of Chengdu,Chengdu,Sichuan 611130,China)

机构地区：[1]成都市第五人民医院中西医结合科

出　　处：《中国现代医学杂志》2020年第2期99-103,共5页China Journal of Modern Medicine

摘　　要：目的探讨自拟清肺宽胸理气汤对慢性阻塞性肺疾病(以下简称慢阻肺)急性加重期患者的疗效。方法选取2015年4月-2018年5月成都市第五人民医院收治的91例慢阻肺急性加重期患者,以随机法分为对照组和联合组。对照组给予西医治疗,联合组给予西医联合自拟清肺宽胸理气汤治疗。对比两组治疗前后中医证候积分、肺功能、血气分析指标变化、临床疗效及不良反应。结果两组治疗后中医证候积分均低于治疗前(P<0.05),联合组治疗后中医证候积分低于对照组(P<0.05),两组治疗后FEV1、FVC和FEV1/FVC高于治疗前(P <0.05),联合组治疗后FEV1、FVC和FEV1/FVC高于对照组(P <0.05),两组治疗后PaO2和pH值高于治疗前(P<0.05),PaCO2低于治疗前(P<0.05),联合组治疗后PaO2和pH值高于对照组(P <0.05),PaCO2低于对照组(P <0.05),联合组总有效率高于对照组(P <0.05)。结论慢阻肺急性加重期患者在西医治疗的基础上给予自拟清肺宽胸理气汤能够显著控制症状,改善肺功能和血气分析指标,增强西医治疗效果,且不会增加不良反应。Objective To explore and analyze the effect of self-made Qingfeikuanxiongliqi decoction on patients with acute exacerbation of chronic obstructive pulmonary disease. Methods A total of 91 patients with acute exacerbation of chronic obstructive pulmonary disease admitted from April 2015 to May 2018 were randomly divided into western medicine group(45 cases) and combination group(46 cases). Western medicine group was treated by western medicine, while the combination group was treated by western medicine combined with self-made Qingfeikuanxiongliqi decoction. The changes of TCM syndrome scores, lung function, blood gas analysis indexes, clinical efficacy and adverse reactions before and after treatment were compared. Results After treatment, while the scores of TCM syndromes and PaCO2 in the two groups decreased(P < 0.05), those in the combined group were lower than those in the western medicine group(P < 0.05). After treatment, FEV1, FVC, FEV1/FVC, PaO2 and pH value of the two groups increased(P < 0.05), and those of the combined group were higher than those of the western medicine group(P < 0.05). The total effective rate of the combined group was higher than that of the western medicine group(P < 0.05). There was no significant difference in the incidences of adverse reactions between the combined group and the western medicine group(P > 0.05). Conclusion On the basis of western medicine treatment, self-made Qingfeikuanxiongliqi decoction can significantly control symptoms, improve pulmonary function and blood gas analysis indexes, enhance the therapeutic effect of western medicine, and will not significantly increase adverse reactions.

关 键 词：肺疾病 慢性阻塞性 清肺宽胸理气汤/中草药 治疗效果 

分 类 号：R563.4[医药卫生—呼吸系统]