基于COMSOL Multiphysics的叉指微电极细胞传感器仿真研究  

Simulation Research on Interdigitated Microelectrode Cell Sensor Based on COMSOL Multiphysics

作　　者：赵雨秋 崔传金 何宁 张学超[3] 李洋博 ZHAO Yuqiu;CUI Chuanjin;HE Ning;ZHANG Xuechao;LI Yangbo(Yisheng College,North China University of Science and Technology,Tangshan 063210,Hebei,China;College of Electrical Engineering,North China University of Science and Technology,Tangshan 063210,Hebei,China;Tongren University,Tongren 554300,Guizhou,China)

机构地区：[1]华北理工大学以升创新教育基地,河北唐山063210 [2]华北理工大学电气工程学院,河北唐山063210 [3]铜仁学院,贵州铜仁554300

出　　处：《实验室研究与探索》2019年第12期116-121,共6页Research and Exploration In Laboratory

基　　金：河北省教育厅项目(ZD2016070);大学生创新项目(X2016060);河北省食品药品监督管理局项目(QN2015012)

摘　　要：叉指微电极阻抗传感器具有快速、准确检测生物非均匀体系中细胞含量的优势。针对牛奶中体细胞含量准确检测难的问题,在COMSOL Multiphysics仿真软件AC/DC模块下的电流接口中构建了以石英玻璃为衬底,指厚100 nm,指长1 mm,指宽分别为10、20、30、40、50μm的A、B、C、D、E 5个三维金叉指微电极模型。对传感器进行了电场的仿真研究,比较了5个不同电极尺寸结构下的电场分布情况,并在频域信号下对5种尺寸的传感器加入不同细胞含量的牛奶样品后进行了仿真检测研究。结果表明,50μm的传感器结构最优,为实际的生物传感器的加工提供了很好的参考。Interdigitated microelectrode impedance sensor has the advantages of rapid and accurate in detecting biological cells in non-homogeneous system,but it is difficult to make a rapid and accurate detection of somatic cells in milk.Thus,5 three-dimensional gold interdigitated microelectrode models named A,B,C,D and E are established based on COMSOL Multiphysics simulation software.In the current interface under its AC/DC module,the sensor model uses 100 nm thick quartz glass as substrate,and 1mm long gold fingers,the finger widths are 10,20,30,40 and 50 micron,respectively.The electric field of the sensor is simulated,and the electric field distribution under 5 different electrode size structures is compared.Milk samples with different cell contents are added to the sensors and the simulation measurement is carried out in the frequency domain.The results showed that the sensor structure with the size of 50 microns is the best one,which provides a good theoretical reference for the actual biosensor design.

关 键 词：叉指微电极 电极结构 3D建模 仿真检测 

分 类 号：TP216[自动化与计算机技术—检测技术与自动化装置]