磁共振功能成像DWI评价含碘对比剂对兔肾脏水分子扩散运动影响的实验研究  

Effects of iodinated contrast agents on renal for the limited diffusion of water molecules in rabbits by functional MRI of DWI

作　　者：王佳欢[1] 周菲[1] 魏宝春[1] 林红[1] Wang Jiahuan;Zhou Fei;Wei Baochun;Lin Hong(Department of Radiology,Jilin Central Hospital,Jilin,Jilin 132000,China)

机构地区：[1]吉林市中心医院影像中心

出　　处：《影像研究与医学应用》2020年第1期19-20,共2页Journal of Imaging Research and Medical Applications

基　　金：吉林省卫生计生青年科技骨干培养计划项目（2016Q003）

摘　　要：目的:应用磁共振功能成像DWI评价不同浓度含碘对比剂对兔肾脏水分子扩散运动影响的实验研究。方法:给予对照组和实验组家兔分别注射生理盐水和不同浓度的含碘对比剂(240,300,350mgI/ml),注射后1,24,48,72h进行DWI-MRI检查。结果:含碘对比剂可以降低肾脏皮质和髓质的ADC值,在48h达到最低值,之后呈上升趋势,并且随含碘对比剂浓度的增加,这一效果更显著,350对比剂组最为明显,特别是髓质。结论:含碘对比剂可以影响家兔肾脏髓质的水分子扩散,特别是在注射对比剂后的48h,以350对比剂组最显著。Objective To evaluate the damaging effects of iodinated contrast agents used for DWI-MRI in rabbit model.Methods DWI-MRI was performed using saline or iodinated contrast agents(240,300 and 350 mgI/ml)at 1,24,48,and 72 h in rabbits.Results ADC values decreased reaching minimum levels at 48h,and increased at 72h,with the 350 treatment having the lowest values.Conclusions The limited diffusion of water molecules is greatest in the renal medulla at 48h.

关 键 词：DWI-MRI 含碘对比剂 肾脏 兔 

分 类 号：R445[医药卫生—影像医学与核医学]