红树植物瓶花木枝叶中化学成分研究  

Chemical constituents from stems and leaves of mangrove plant, Scyphiphora hydrophyllacea

作　　者：李玉洁 唐浩轩 李娟[2,3] 谢澜 曹雯清 刘艳萍[2,3] 付艳辉[1,2,3] LI Yu-jie;TANG Hao-xuan;LI Juan;XIE Lan;CAO Wen-qing;LIU Yan-ping;FU Yan-hui(School of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;Engineering Research Center for Industrialization of Southern Medicinal Plants Resources of Hainan Province,Hainan Normal University,Haikou 571158,China;Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education,Hainan Normal University,Haikou 571158,China)

机构地区：[1]福建中医药大学药学院,福建福州350122 [2]海南师范大学南药资源产业化关键技术研究海南省工程研究中心,海南海口571158 [3]海南师范大学热带药用资源化学教育部重点实验室,海南海口571158

出　　处：《中草药》2019年第23期5677-5682,共6页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目（21967008）;国家自然科学基金资助项目（21662011）;国家自然科学基金资助项目（31660097）;海南省重点研发计划项目（ZDYF2019049）;海口市重点研发计划项目（2017050）;教育部创新团队项目（IRT-16R19）

摘　　要：目的研究红树植物瓶花木Scyphiphora hydrophyllacea枝叶中的化学成分。方法综合运用正、反相硅胶柱色谱和SephadexLH-20凝胶柱色谱以及制备型高效液相色谱等方法进行系统分离纯化,根据化合物的理化性质及其波谱学数据鉴定化合物的结构。结果从瓶花木枝叶的90%乙醇提取物中分离得到了18个化合物,分别鉴定为坡模酮酸(1)、蔷薇酸(2)、达玛二烯醇乙酸酯(3)、古柯二醇(4)、羽扇豆醇乙酸酯(5)、30-醛基羽扇豆醇(6)、山楂酸(7)、23-羟基熊果酸(8)、β-香树脂酮(9)、刺槐素(10)、金圣草黄素(11)、棕矢车菊素(12)、熊竹山姜素(13)、异樱花素(14)、花旗松素(15)、lyoniresinol(16)、杜仲树脂酚(17)和蛇菰脂醛素(18)。其中,化合物1~9为三萜类化合物,10~15为黄酮类化合物,16~18为木脂素类化合物。结论所有化合物均为首次从瓶花木属植物中分离得到。Objective To study the chemical constituents of the stems and leaves of mangrove plant,Scyphiphora hydrophyllacea.Methods The chemical constituents of S.hydrophyllacea were separated and purified by silica gel,ODS,Sephadex LH-20 gel column chromatographies and preparative HPLC.Their structures were identified by physicochemical properties,spectroscopic analysis,as well as comparisons with the data reported in literatures.Results A total of 18 compounds were isolated from the 90%ethanol extract of the stems and leaves of S.hydrophyllacea,which were identified as pomonic acid(1),euscaphic acid(2),dammaradienyl acetate(3),erythrodiol(4),lupenyl acetate(5),30-oxo-lupeol(6),maslinic acid(7),23-hydroxyursolic acid(8),β-amyrenone(9),acacetin(10),chrysoeriol(11),jaceosidin(12),kumatakenin(13),isosakuranetin(14),taxifolin(15),lyoniresinol(16),medioresinol(17),and balanophonin(18).Compounds 1-9 were triterpenoids,compounds 10-15 were flavonoids and compounds 16-18 were lignans.Conclusion All compounds are isolated from the genus Scyphiphora for the first time.

关 键 词：红树植物 瓶花木 三萜 黄酮 木脂素 坡模酮酸 蔷薇酸 达玛二烯醇乙酸酯 古柯二醇 

分 类 号：R284.1[医药卫生—中药学]